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HISAO MORIYA

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I am an Associate Professor of Research Core for Interdisciplinary Sciences (RCIS), Okayama University. I completed my Ph.D in Biology from Kobe University in 1998 under the supervision of Professor Katsumi Isono. After engagement in the study of the glucose sensing system in yeast at Prof. Mark Johnston’s lab in Washington University, I joined to Dr. Hiroaki Kitano’s group (Kitano Symbiotic Systems Project, JST), where I started the study on robustness of cellular systems which is the main topic of my current research. In 2006, I was selected as a researcher of JST PRESTO project ‘‘The Dynamic Mechanism of and Fundamental Technology for Biological System’’. In 2009, I moved to Okayama University where I started my own group.

Contact Information

Research Projects

The aims of my research group are to understand design principles of cellular systems, to develop integrative cellular computational models, and to develop means to find novel therapeutic drug targets. All these aims are performed through an experimental technology designated “genetic Tug-Of-War (gTOW)”, which we have originally developed (Moriya et al., 2006, Moriya et al., 2012).

1. genetic Tug-Of-War (gTOW) method

The gTOW method is a genetic method to argue cellular robustness against overexpression of a certain gene. Using gTOW, we have analyzed robustness of the cell cycles of the budding yeast S. cerevisiae (Kaizu et al., 2010), and the fission yeast S. pombe (Moriya et al., 2011). We also performed the genome-wide gTOW analysis of the budding yeast, and isolated 115 “dosage sensitive genes” (Makanae et al., 2013).

2. Cellular Computational Model

We are developing integrative computational models using the yeast cell cycle as a model system. We have succeeded to establish a research scheme to evaluate computational models with gTOW data, to find regulations not implemented in the model, and to refine the model (Kaizu et al., 2010, Moriya et al., 2011).

3. Molecular Genetic Technologies in Yeast

A DNA cloning technology using cellular homologous recombination activity (GRC) is highly convenient, effective, and flexible in the design. We thus expect that GRC will be one of the central DNA cloning technology. We have performed a collaborative work with Dr. Watanabe (Shizuoka Univ.) to clone and express polyketide synthase encoded on fungal genomes using GRC in yeasts (Ishiuchi et al., 2012). We have published about the systematic scheme to use GRC in the fission yeast (Chino et al., 2010). We also performed a genome-wide terminator analysis of the budding yeast (Yamanishi et al., 2013).

Publications

 
2017-09-26 (火) 07:28:18