{"id":2863,"date":"2014-03-25T12:52:30","date_gmt":"2014-03-25T03:52:30","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=2863"},"modified":"2014-05-23T09:06:07","modified_gmt":"2014-05-23T00:06:07","slug":"%e3%80%8ccelldesigner4-3%e3%81%a7cell-cycle%e3%83%a2%e3%83%87%e3%83%ab%e3%82%92%e5%86%8d%e6%a7%8b%e7%af%89%e3%81%97%e3%81%a6%e3%81%bf%e3%82%88%e3%81%86%ef%bc%88%ef%bc%94-%e6%9c%80%e7%b5%82%e5%9b%9e","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=2863","title":{"rendered":"CellDesigner4.3\u3067Cell Cycle\u30e2\u30c7\u30eb\u3092\u518d\u69cb\u7bc9\u3057\u3066\u307f\u3088\u3046\uff08\uff14 \u6700\u7d42\u56de\uff09"},"content":{"rendered":"<p>\u300c<a title=\"CellDesigner4.3\u3067Cell Cycle\u30e2\u30c7\u30eb\u3092\u518d\u69cb\u7bc9\u3057\u3066\u307f\u3088\u3046\uff08\uff13\uff09\" href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=2832\" target=\"_blank\">CellDesigner4.3\u3067Cell Cycle\u30e2\u30c7\u30eb\u3092\u518d\u69cb\u7bc9\u3057\u3066\u307f\u3088\u3046\uff08\uff13\uff09<\/a>\u300d\u306e\u7d9a\u304d\u3067\u3059\u3002<\/p>\n<p>\u3044\u308d\u3093\u306a\u30a8\u30e9\u30fc\u304c\u3042\u3063\u3066\u52d5\u304b\u306a\u3044\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u52d5\u304f\u3088\u3046\u306b\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h5>\u30e2\u30c7\u30eb\u306e\u30a8\u30e9\u30fc\u3092\u4fee\u6b63\u3059\u308b\uff081\/2\uff09\uff1a\u30b7\u30df\u30e5\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u52d5\u304f\u307e\u3067<\/h5>\n<p>\u307e\u305a\u306f\u30a8\u30e9\u30fc\u306e\u7a2e\u985e\u3002Simulation\u7528\u306eControl panel\u304c\u958b\u304f\u304b\u3069\u3046\u304b\u3001\u5927\u62b5\u306e\u5834\u5408\u3053\u3053\u3067\u30a8\u30e9\u30fc\u304c\u51fa\u307e\u3059\u3002\u3053\u306e\u6642\u306f\u4f55\u304c\u304a\u304b\u3057\u3044\u306e\u304b\u8868\u793a\u3057\u3066\u304f\u308c\u307e\u3059\u306e\u3067\u3001\u305d\u308c\u3092\u898b\u306a\u304c\u3089\u76f4\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>\u4e00\u756a\u591a\u3044\u306e\u306f\u3001\u5909\u6570\u3084\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u540d\u524d\u304c\u9593\u9055\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002\u6570\u5f0f\u306b\u51fa\u3066\u304f\u308b\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u304c\u3069\u3053\u306b\u3082\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u30a8\u30e9\u30fc\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u30e1\u30c3\u30bb\u30fc\u30b8\u3092\u3082\u3068\u306b\u3072\u3068\u3064\u3065\u76f4\u3057\u3066\u3044\u3051\u3070\u89e3\u6c7a\u3057\u307e\u3059\u3002<\/p>\n<p>\u3081\u3067\u305f\u304fControl\u30d1\u30cd\u30eb\u304c\u958b\u304f\u3088\u3046\u306b\u306a\u3063\u305f\u3089\u3001Execute\u3067\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u8d70\u3089\u305b\u307e\u3059\u3002\u3053\u306e\u6642\u306b\u6ce8\u610f\u3059\u308b\u306e\u306f\u3001\u300cCOPASI\u300d\u306eSolver\u3092\u4f7f\u3046\u3053\u3068\u3002\u6a19\u6e96\u306eSOSlib solver\u3067\u306f\u3053\u306e\u30e2\u30c7\u30eb\u306f\u52d5\u304d\u307e\u305b\u3093\uff08\u30a4\u30d9\u30f3\u30c8\u304c\u3042\u308b\u305b\u3044\u3089\u3057\u3044\u3067\u3059\uff09\u3002COPASI solver\u304c\u30a4\u30f3\u30b9\u30c8\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u306b\u306f\u3001<a title=\"CellDesigner COPASI\" href=\"http:\/\/www.celldesigner.org\/help\/CDH_Inst_21.html\" target=\"_blank\">\u3053\u306e\u30da\u30fc\u30b8<\/a>\u3092\u3082\u3068\u306b\u30a4\u30f3\u30b9\u30c8\u30fc\u30eb\u3057\u3066\u304a\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001Execute\u306e\u30dc\u30bf\u30f3\u3092\u62bc\u3057\u307e\u3059\u3002\u79c1\u306e\u5834\u5408\u306b\u306f\u3053\u3053\u3067\u30a8\u30e9\u30fc\u304c\u51fa\u3066\u4f55\u3082\u52d5\u304b\u306a\u304f\u306a\u308a\u307e\u3057\u305f\u3002CellDesigner4.3\u3092\u5f37\u5236\u7d42\u4e86\u3057\u3066\u3001\u7acb\u3061\u4e0a\u3052\u76f4\u3057\u4f55\u304c\u304a\u304b\u3057\u3044\u306e\u304b\u539f\u56e0\u3092\u7a76\u660e\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3057\u3088\u3046\u3068\u3059\u308b\u3068CellDesigner4.3\u304c\u7a81\u7136\u7d42\u4e86\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3068\u3044\u3046\u304b\u3001\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\u3001\u30a8\u30e9\u30fc\u304c\u306a\u304f\u3066\u3082\u305f\u3073\u305f\u3073\u7d42\u4e86\u3057\u307e\u3059\u3002\u30e2\u30c7\u30eb\u306e\u30d5\u30a1\u30a4\u30eb\u306f\u3053\u307e\u3081\u306b\u4fdd\u5b58\u3057\u3066\u304a\u3044\u305f\u307b\u3046\u304c\u826f\u3044\u3067\u3059\u3002<\/p>\n<p>CellDesigner4.3\u306f\u3001Reactions\u306b\u66f8\u304b\u308c\u305f\u5fae\u5206\u65b9\u7a0b\u5f0f\u306b\u30a8\u30e9\u30fc\u304c\u306a\u3044\u304b\u306e\u652f\u63f4\u306f\u3068\u3066\u3082\u5f37\u529b\u306a\u306e\u3067\uff08\u6c17\u3065\u304d\u3084\u3059\u3044\u306e\u3067\uff09\u3001\u4e0a\u624b\u304f\u52d5\u304b\u306a\u3044\u6642\u306e\u30a8\u30e9\u30fc\u306f\u5927\u62b5\u3001Rules\u306eAssignment\u304bEvents\u306b\u539f\u56e0\u304c\u6709\u308a\u307e\u3059\u3002\u305d\u3046\u3067\u306a\u3051\u308c\u3070\u3044\u305a\u308c\u306b\u305b\u3088\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u52d5\u304f\u304b\u3089\u3067\u3059\u3002<\/p>\n<p>\u79c1\u306e\u5834\u5408\u306b\u3082Assignment\u306e\u30a8\u30e9\u30fc\uff08\u3053\u308c\u306f\u5358\u7d14\u306b\u30a8\u30e9\u30fc\u3068\u306f\u3044\u3048\u306a\u3044\u3001\u300cVariables\u3068Parameter\u306e\u9055\u3044\u300d\u3042\u308b\u3044\u306f\u3001\u300c\u63cf\u753b\u3068\u30e2\u30c7\u30eb\u69cb\u9020\u306e\u30b3\u30f3\u30d5\u30ea\u30af\u30c8\u300d\u304c\u539f\u56e0\u3060\u3063\u305f\u308a\u3082\u3057\u307e\u3059\uff09\u3092\u4fee\u6b63\u3057\u3001\u306a\u3093\u3068\u304b\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u8d70\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_2878\" aria-describedby=\"caption-attachment-2878\" style=\"width: 568px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/329e18b4968c2868f3b943f9ea5f2b3a.png\"><img fetchpriority=\"high\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/329e18b4968c2868f3b943f9ea5f2b3a.png\" alt=\"\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\uff1a\u52d5\u304f\u3088\u3046\u306b\u306f\u306a\u3063\u305f\u304c\u30fb\u30fb\u30fb\u3002\" width=\"568\" height=\"359\" class=\" wp-image-2878   \" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/329e18b4968c2868f3b943f9ea5f2b3a.png 810w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/329e18b4968c2868f3b943f9ea5f2b3a-300x189.png 300w\" sizes=\"(max-width: 568px) 100vw, 568px\" \/><\/a><figcaption id=\"caption-attachment-2878\" class=\"wp-caption-text\">\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\uff1a\u52d5\u304f\u3088\u3046\u306b\u306f\u306a\u3063\u305f\u304c\u30fb\u30fb\u30fb\u3002<\/figcaption><\/figure>\n<p>\u3068\u3053\u308d\u304c\u3001\u7d30\u80de\u5468\u671f\u306e\u7279\u5fb4\u3067\u3042\u308b\u300c\u5468\u671f\u89e3\u300d\u304c\u3067\u307e\u305b\u3093\u3002\u5468\u671f\u3092\u8d77\u3053\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u8981\u7d20\u9593\u306e\u9023\u643a\u304c\u304d\u3061\u3093\u3068\u3068\u308c\u3066\u3044\u306a\u3044\u3068\u30c0\u30e1\u306a\u306e\u3067\u3001\u591a\u5206\u3069\u3053\u304b\u306b\u7d30\u304b\u3044\u30a8\u30e9\u30fc\u304c\u3042\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002\u305d\u308c\u3092\u307e\u305f\u63a2\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h5>\u30e2\u30c7\u30eb\u306e\u30a8\u30e9\u30fc\u3092\u4fee\u6b63\u3059\u308b\uff082\/2\uff09\uff1a\u30a8\u30e9\u30fc\u306e\u5834\u6240\u3092\u300c\u751f\u7269\u5b66\u7684\u306b\u300d\u63a2\u3059<\/h5>\n<p>\u30a8\u30e9\u30fc\u30e1\u30c3\u30bb\u30fc\u30b8\u304c\u306a\u3044\u304c\u3001\u601d\u3044\u901a\u308a\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\u304c\u51fa\u306a\u3044\u3002\u3053\u3053\u304b\u3089\u304c\u4e00\u756a\u5927\u5909\u306a\u3068\u3053\u308d\u3067\u3059\u3002\u3053\u308c\u3060\u3051\u8907\u96d1\u306a\u30e2\u30c7\u30eb\u306b\u306a\u3063\u3066\u304f\u308b\u3068\u4eba\u9593\u306e\u76ee\u3067\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3084\u6570\u5f0f\u306e\u308f\u305a\u304b\u306a\u9593\u9055\u3044\u3092\u63a2\u3059\u306e\u306f\u5bb9\u6613\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u3053\u304b\u3089\u306f\u300c\u751f\u7269\u5b66\u7684\u306b\u300d\u30a8\u30e9\u30fc\u3092\u898b\u3064\u3051\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u5b9f\u306f\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u3001\u30e2\u30c7\u30eb\u304c\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u751f\u7269\u5b66\u7684\u77e5\u8b58\u3092\u80cc\u666f\u306b\u4f5c\u3089\u308c\u3066\u3044\u308b\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u306e\u306b\u3068\u3066\u3082\u5f79\u306b\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p>\u57fa\u672c\u7684\u306a\u3084\u308a\u65b9\u306f\u3001\u300cBioModels\u304b\u3089\u5165\u624b\u3067\u304d\u308b<a title=\"Chen2004\u30e2\u30c7\u30eb\" href=\"http:\/\/www.ebi.ac.uk\/biomodels-main\/BIOMD0000000056\" target=\"_blank\">\u30e2\u30c7\u30eb<\/a>\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\uff08\u6b63\u89e3\uff09\u3068\u3001\u81ea\u5206\u304c\u4f5c\u3063\u3066\u3044\u308b\u9014\u4e2d\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u7d50\u679c\u3092\u3058\u3063\u304f\u308a\u3068\u6bd4\u3079\u3066\u3001\u3069\u306e\u3088\u3046\u306a\u53cd\u5fdc\u304c\u8d77\u304d\u3066\u3044\u306a\u3044\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3001\u305d\u306e\u90e8\u5206\u306b\u3042\u308b\u30a8\u30e9\u30fc\u3092\u898b\u3064\u3051\u4fee\u6b63\u3059\u308b\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u4f5c\u696d\u3092\u751f\u7269\u5b66\u7684\u306b\u3068\u3089\u3048\u3066\u3001\u6b63\u89e3\u306e\u30e2\u30c7\u30eb\u3092\u300c\u91ce\u751f\u578b\u7d30\u80de\u300d\u3001\u81ea\u5206\u304c\u4f5c\u3063\u3066\u3044\u308b\u9014\u4e2d\u306e\u30a8\u30e9\u30fc\u304c\u3042\u308b\u30e2\u30c7\u30eb\u3092\u300c\u5909\u7570\u578b\u7d30\u80de\u300d\u3068\u8003\u3048\u3066\u3001\u4f55\u304c\u8d77\u304d\u3066\u3044\u306a\u3044\u304b\u3089\u3053\u306e\u5909\u7570\u7d30\u80de\u306f\u304a\u304b\u3057\u306a\u632f\u308b\u821e\u3044\u3092\u3059\u308b\u306e\u304b\u3092\u8003\u3048\u3001\u305d\u308c\u3092\u623b\u3057\u3066\u3084\u308b\u3068\u3044\u3046\u98a8\u306b\u8003\u3048\u308b\u306e\u3067\u3059\u3002\u3053\u308c\u304c\u30a8\u30e9\u30fc\u4fee\u6b63\u306e\u6700\u77ed\u306e\u65b9\u6cd5\u306f\u3069\u3046\u304b\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u304c\u3001\u3053\u3046\u3059\u308b\u3068\u3044\u308d\u3044\u308d\u52c9\u5f37\u306b\u306a\u308b\u3057\u3001\u30a8\u30e9\u30fc\u4fee\u6b63\u306e\u904e\u7a0b\u3082\u697d\u3057\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u4ee5\u4e0b\u3001\u79c1\u304c\u884c\u3063\u305f\u4ee3\u8868\u7684\u306a5\u3064\u306e\u4fee\u6b63\u306b\u3064\u3044\u3066\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8aac\u660e\u3057\u307e\u3059\u3002\u610f\u5473\u306f\u307b\u3068\u3093\u3069\u308f\u304b\u3089\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u96f0\u56f2\u6c17\u304c\u4f1d\u308f\u308c\u3070\u3002<\/p>\n<h6>\uff08\uff11\uff09\u5468\u671f\u304c\u51fa\u306a\u3044\u3002<\/h6>\n<p>\u5468\u671f\u3092\u8d77\u3053\u3059\u306e\u306b\u91cd\u8981\u306aCDK\uff08Clb2, CLb5\uff09\u306e\u6d3b\u6027\u5316\u306f\u8d77\u304d\u3066\u3044\u308b\u304b\uff1f \uff1a\u8d77\u304d\u3066\u3044\u306a\u3044\uff08\u2613\uff09\u3002\u3067\u306f\u3001CDK\u306e\u8ee2\u5199\u6d3b\u6027\u5316\u306f\uff1f\uff1a\u30bf\u30a4\u30e0\u30ea\u30fc\u306b\u8d77\u304d\u3066\u3044\u308b\uff08\u25ef\uff09\u3002\u3067\u306f\u3001CDK\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u306a\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\uff08Sic1, Cdc6\uff09\u306e\u4e0d\u6d3b\u6027\u5316\u306f\uff1f\uff1a\u8d77\u304d\u3066\u3044\u306a\u3044\uff08\u2613\uff09\u3002\u3067\u306f\u3001\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\u306e\u6d3b\u6027\u5236\u5fa1\u306b\u95a2\u308f\u308b\u30d5\u30a9\u30b9\u30d5\u30a1\u30bf\u30fc\u30bcCdc14\u306e\u5236\u5fa1\u306f\uff1f\uff1a\u6319\u52d5\u304c\u304a\u304b\u3057\u3044\uff08\u2613\uff09\u3002\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u9593\u9055\u3044\u767a\u898b\u30fb\u4fee\u6b63\uff1aCdc14\u306e\u6319\u52d5\u304c\u307e\u3060\u304a\u304b\u3057\u3044\u3002\u3067\u306f\u3001Cdc14\u306e\u5236\u5fa1\u3092\u884c\u3046Cdc15\u306e\u6319\u52d5\u306f\uff1f\uff1a\u304a\u304b\u3057\u3044\uff08\u2613\uff09\u3002Cdc15\u306e\u5236\u5fa1\u306e\u5f0f\u306b\u9593\u9055\u3044\u3092\u767a\u898b\u3001\u4fee\u6b63\uff1a\u307e\u3060Cdc14\u306e\u6319\u52d5\u304c\u304a\u304b\u3057\u3044\u3002Cdc14\u306e\u30a4\u30f3\u30d2\u30d3\u30bf\u30fcNet1\u306e\u30ea\u30f3\u9178\u5316\u3092\u884c\u306a\u3046PPX\u306e\u632f\u308b\u821e\u3044\u304c\u9055\u3046\uff08\u2613\uff09\u3002\u3067\u306f\u3001PPX\u306e\u5206\u89e3\u306b\u542b\u307e\u308c\u308bPds1\u306e\u6319\u52d5\u306f\uff1f\uff1a\u30bf\u30a4\u30e0\u30ea\u30fc\u306b\u4e0a\u304c\u3063\u3066\u304d\u3066\u3044\u306a\u3044\uff08\u2613\uff09\u3002\u3067\u306f\u3001Pds1\u306e\u5206\u89e3\u3092\u884c\u306a\u3046Cdc20\u306e\u632f\u308b\u821e\u3044\u306f\uff1f\uff1a\u9ad8\u3059\u304e\u308b\uff08\u2613\uff09\u3002Cdc20\u306e\u5236\u5fa1\u306b\u304b\u304b\u308f\u308b\u5f0f\u3092\u5165\u308c\u5fd8\u308c\u3066\u3044\u305f\u3002Cdc14\u306e\u6319\u52d5\u306f\u6b63\u89e3\u3068\u307b\u307c\u304a\u306a\u3058\u306b\u306a\u3063\u305f\u3002<\/p>\n<figure id=\"attachment_2880\" aria-describedby=\"caption-attachment-2880\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/f69aaf6b1f2c9af6cd4683a15af48fb1.png\"><img decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/f69aaf6b1f2c9af6cd4683a15af48fb1-1024x468.png\" alt=\"Cdc14\u5236\u5fa1\u306e\u6319\u52d5\uff08\u6b63\u89e3\uff09\" width=\"580\" height=\"265\" class=\"size-large wp-image-2880\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/f69aaf6b1f2c9af6cd4683a15af48fb1-1024x468.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/f69aaf6b1f2c9af6cd4683a15af48fb1-300x137.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/f69aaf6b1f2c9af6cd4683a15af48fb1.png 1282w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2880\" class=\"wp-caption-text\">Cdc14\u5236\u5fa1\u306e\u6319\u52d5\uff08\u6b63\u89e3\uff09<\/figcaption><\/figure>\n<figure id=\"attachment_2881\" aria-describedby=\"caption-attachment-2881\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/0c2f03df37e1bdfd08d48542e544908e.png\"><img decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/0c2f03df37e1bdfd08d48542e544908e-1024x547.png\" alt=\"Cdc14\u5236\u5fa1\u306e\u6319\u52d5\uff08\u30a8\u30e9\u30fc\u3042\u308a\uff09\" width=\"580\" height=\"309\" class=\"size-large wp-image-2881\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/0c2f03df37e1bdfd08d48542e544908e-1024x547.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/0c2f03df37e1bdfd08d48542e544908e-300x160.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/0c2f03df37e1bdfd08d48542e544908e.png 1133w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2881\" class=\"wp-caption-text\">Cdc14\u5236\u5fa1\u306e\u6319\u52d5\uff08\u30a8\u30e9\u30fc\u3042\u308a\uff09<\/figcaption><\/figure>\n<h6>\uff08\uff12\uff09\u3060\u304c\u307e\u3060\u5468\u671f\u304c\u51fa\u306a\u3044\u3002<\/h6>\n<p>\u4e0a\u8a18\uff12\u306e\u904e\u7a0b\u3067Cdc20\u306e\u5236\u5fa1\u306b\u3064\u3044\u3066\u3044\u304f\u3064\u304b\u306e\u5f0f\u3092\u5165\u308c\u5fd8\u308c\u3066\u3044\u305f\u3053\u3068\u3092\u767a\u898b\u3002Mad2\u306e\u30a4\u30d9\u30f3\u30c8\u3092\u4fee\u6b63\u3002\u3053\u3053\u304b\u3089\u5468\u671f\u304c\u767a\u751f\u3059\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3002<\/p>\n<h6>\uff08\uff13\uff09\u5024\u304c\u30de\u30a4\u30ca\u30b9\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/h6>\n<p>Clb5\u306e\u5024\u304c\u30de\u30a4\u30ca\u30b9\u306b\uff08\u2613\uff09\u3002\u3067\u306f\u3001Clb5\u306e\u5206\u89e3\u3092\u884c\u306a\u3046Cdc20\u306e\u5024\u306f\uff1f\uff1a\u30de\u30a4\u30ca\u30b9\u306b\u306a\u3063\u3066\u3044\u308b\uff08\u2613\uff09\u3002\u3067\u306f\u3001Cdc20\u306e\u6d3b\u6027\u5316\u3092\u884c\u306a\u3046APC-P\u306e\u5024\u306f\uff1f\uff1a\u30de\u30a4\u30ca\u30b9\u306b\u306a\u3063\u3066\u3044\u308b\uff08\u2613\uff09\u3002APC-P\u304cCdc20\u306e\u6d3b\u6027\u5316\u3092\u884c\u306a\u3046\u5f0f\u306b\u9593\u9055\u3044\u3092\u767a\u898b\uff08\u4f1a\u5408\u3067\u306f\u306a\u304f\u6d3b\u6027\u5316\u3060\u3063\u305f\uff09\u3002 Clb5\u306e\u30de\u30a4\u30ca\u30b9\u554f\u984c\u306f\u89e3\u6c7a\u3057\u305f\u3002<\/p>\n<p>\u30de\u30a4\u30ca\u30b9\u306b\u306a\u308b\u306e\u306f\u3001\u5927\u62b5\u306e\u5834\u5408Mass action\u3084Michaelis-Menten\u5f0f\u306eSubstrate\u306b\u30a8\u30c3\u30b8\u306e\u51fa\u767a\u70b9\u306e\u8981\u7d20\u304c\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u539f\u56e0\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_2882\" aria-describedby=\"caption-attachment-2882\" style=\"width: 591px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/804177c9417fa047388f86a2041ab5b3.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/804177c9417fa047388f86a2041ab5b3.png\" alt=\"\u30e2\u30c7\u30eb\u4fee\u6b63\u9014\u4e2d\uff08\u30de\u30a4\u30ca\u30b9\u306b\u306a\u308b\u306e\u306f\u304a\u304b\u3057\u3044\uff09\" width=\"591\" height=\"337\" class=\" wp-image-2882 \" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/804177c9417fa047388f86a2041ab5b3.png 985w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/804177c9417fa047388f86a2041ab5b3-300x171.png 300w\" sizes=\"(max-width: 591px) 100vw, 591px\" \/><\/a><figcaption id=\"caption-attachment-2882\" class=\"wp-caption-text\">\u30e2\u30c7\u30eb\u4fee\u6b63\u9014\u4e2d\uff08\u30de\u30a4\u30ca\u30b9\u306b\u306a\u308b\u306e\u306f\u304a\u304b\u3057\u3044\uff09<\/figcaption><\/figure>\n<h6>\uff08\uff14\uff09DNA\u8907\u88fd\u8d77\u70b9\uff08ORI\uff09\u306e\u4e0a\u6607\u5ea6\u5408\u3044\u304c\u9045\u3044\uff08\u30b5\u30a4\u30af\u30eb\u304c\u9045\u5ef6\u3059\u308b\uff09\u3002<\/h6>\n<p>ORI\u306e\u5f0f\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u66f8\u304d\u9593\u9055\u3044\uff08Clb2\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fceorib2\u3068\u66f8\u304f\u3079\u304d\u3068\u3053\u308d\u3092Clb5\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fceorib5\u3092\u66f8\u3044\u3066\u3044\u305f\uff09\u3002\u4fee\u6b63\u3057\u305f\u3089\u3001ORI\u306e\u4e0a\u6607\u5ea6\u5408\u3044\u304c\u4eca\u5ea6\u306f\u65e9\u904e\u304e\u308b\u3002Clb5\u306e\u6d3b\u6027\u4e0a\u6607\u304c\u65e9\u904e\u304e\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002Clb5\u306e\u5206\u89e3\u9175\u7d20Cdc20\u306e\u6d3b\u6027\u5236\u5fa1\u306fOK\u3002Clb5\u306e\u30a4\u30f3\u30d2\u30d3\u30bf\u30fc\uff08CKI)\u304c\u6b63\u89e3\u3088\u308a\u3082\u65e9\u304f\u5931\u308f\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\uff08\u2613\uff09\u3002\u3067\u306f\u3001CKI\u306e\u8ee2\u5199\u6d3b\u6027\u5316\u3092\u884c\u306a\u3046Swi5\u306e\u6d3b\u6027\u306f\uff1f\uff1a\u4e0d\u6d3b\u6027\u5316\u3055\u308c\u308b\u306e\u304c\u65e9\u904e\u304e\u308b\uff08\u2613\uff09\u3002Swi5\u306e\u6d3b\u6027\u5316\u3068\u4e0d\u6d3b\u6027\u5316\u306e\u5236\u5fa1\u5f0f\u306b\u9593\u9055\u3044\u3092\u767a\u898b\u3002<\/p>\n<h6>\uff08\uff15\uff09Clb2\u306e\u6d3b\u6027\u304c\u9ad8\u304f\u306a\u308a\u3059\u304e\u308b\u3002<\/h6>\n<p>Clb2\u306e\u30b0\u30e9\u30d5\u306e\u5f62\u304c\u9055\u3046\u3001Anaphase\u3067\u306e\u4e0b\u304c\u308a\u5177\u5408\u304c\u60aa\u3044\uff08\u2613\uff09\u3002Clb2\u306eCdc20\u306b\u3088\u308b\u5206\u89e3\u304c\u8d77\u304d\u3066\u3044\u306a\u3044\uff08\u2613\uff09\u3002Clb2\u306e\u5206\u89e3\u306b\u95a2\u308f\u308b\u5f0f\u306e\u4e2d\u306b\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u9593\u9055\u3044\u3092\u767a\u898b\uff08kdb2_p\u3068kdb2p\u306e\u9593\u9055\u3044\uff09\u3002Clb2\u306e\u6319\u52d5\u306f\u4fee\u6b63\u3055\u308c\u305f\u3002<\/p>\n<figure id=\"attachment_2883\" aria-describedby=\"caption-attachment-2883\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/9178cba228f98abddb19e846ef6a9afd.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/9178cba228f98abddb19e846ef6a9afd-1024x480.png\" alt=\"Clb2\u6d3b\u6027\u5316\uff08\u9752\u3044\u30e9\u30a4\u30f3\uff09\u306e\u6b63\u89e3\u30b0\u30e9\u30d5\" width=\"580\" height=\"271\" class=\"size-large wp-image-2883\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/9178cba228f98abddb19e846ef6a9afd-1024x480.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/9178cba228f98abddb19e846ef6a9afd-300x140.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/9178cba228f98abddb19e846ef6a9afd.png 1289w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2883\" class=\"wp-caption-text\">Clb2\u6d3b\u6027\u5316\u306e\u6b63\u89e3\u30b0\u30e9\u30d5<span style=\"font-size: 10.909090995788574px; line-height: 15px;\">\uff08\u6fc3\u3044\u9752\u306e\u30e9\u30a4\u30f3\uff09<\/span><\/figcaption><\/figure>\n<figure id=\"attachment_2885\" aria-describedby=\"caption-attachment-2885\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/bb4d6788658d98aca0d043bba8fc0140.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/bb4d6788658d98aca0d043bba8fc0140-1024x405.png\" alt=\"Clb2\u6d3b\u6027\u5316\uff08\u30a8\u30e9\u30fc\u3042\u308a\uff09\u306e\u30b0\u30e9\u30d5\uff08\u9752\u3044\u30e9\u30a4\u30f3\uff09\" width=\"580\" height=\"229\" class=\"size-large wp-image-2885\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/bb4d6788658d98aca0d043bba8fc0140-1024x405.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/bb4d6788658d98aca0d043bba8fc0140-300x118.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/bb4d6788658d98aca0d043bba8fc0140.png 1289w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2885\" class=\"wp-caption-text\">Clb2\u6d3b\u6027\u5316\uff08\u30a8\u30e9\u30fc\u3042\u308a\uff09\u306e\u30b0\u30e9\u30d5\uff08\u6fc3\u3044\u9752\u306e\u30e9\u30a4\u30f3\uff09<\/figcaption><\/figure>\n<p>\u3053\u308c\u4ee5\u5916\u306b\u3082\u3044\u308d\u3044\u308d\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u306a\u3093\u3068\u304b\u6b63\u89e3\uff08\u91ce\u751f\u578b\uff09\u3068\u540c\u3058\u6319\u52d5\u3092\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u4e0a\u8a18\u306e\uff14\u3068\u304b\uff15\u3068\u304b\u306e\u7d30\u304b\u3044\u9593\u9055\u3044\u306f\u3001\u3053\u3046\u3044\u3046\u624b\u304c\u304b\u308a\u3092\u4f7f\u3063\u3066\u3044\u304b\u305a\u306b\u898b\u3064\u3051\u308b\u306e\u306f\u975e\u5e38\u306b\u96e3\u3057\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n<p>\u9014\u4e2d\u3044\u304f\u3064\u304b\u3042\u3063\u305f\u30a8\u30e9\u30fc\u3067\u3059\u304c\u3001\u751f\u7269\u5b66\u7684\u306b\u306f\u56e0\u5b50\u306e\u5236\u5fa1\u304c\u304a\u304b\u3057\u304f\u306a\u3063\u305f\u300c\u5909\u7570\u300d\u3067\u3042\u308b\u3068\u8003\u3048\u308b\u3053\u3068\u3082\u51fa\u6765\u307e\u3059\u3002\u4f8b\u3048\u3070\uff14\u306e\u5f8c\u534a\u306f\u300cSwi5\u306e\u30ea\u30f3\u9178\u5316\u5236\u5fa1\u304c\u7834\u7dbb\u3057\u305f\u5909\u7570\u682a\u300d\uff08Swi5\u306f\u5fc5\u9808\u3067\u306f\u306a\u3044\u306e\u3067\u6b7b\u306b\u307e\u305b\u3093\u304c\u3001\u5468\u671f\u306e\u901f\u5ea6\u306b\u7570\u5e38\u304c\u51fa\u308b\uff09\u3001\uff15\u3067\u306f\u300cCdc20\u306b\u3088\u308bClb2\u306e\u5206\u89e3\u52b9\u7387\u304c\u60aa\u304f\u306a\u3063\u305f\u5909\u7570\u300d\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<p>\u5b8c\u6210\u56f3\u3092\u6700\u5f8c\u306b\u8f09\u305b\u307e\u3059\u3002\u82e5\u5e72\u5468\u671f\u901f\u5ea6\u304c\u9055\u3046\u306e\u306f\u6210\u9577\u901f\u5ea6\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u304c\u9055\u3046\u305f\u3081\u3067\u3059\u3002\u3053\u308c\u306f\u8ad6\u6587\u306e\u30e2\u30c7\u30eb\u306b\u306f\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306a\u306e\u3067\u3059\u304c\u3001\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u30e2\u30c7\u30eb\u306b\u306f\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u30b0\u30e9\u30d5\u306e\u8272\u304c\u9055\u3046\u306e\u306f\u3001\u8981\u7d20\u3068\u8272\u306e\u30a2\u30b5\u30a4\u30f3\u304c\u9055\u3046\u304b\u3089\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_2887\" aria-describedby=\"caption-attachment-2887\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/d5d61ab176d60f5f66b8f862e0346430.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/d5d61ab176d60f5f66b8f862e0346430-1024x516.png\" alt=\"\u300c\u6b63\u89e3\u30e2\u30c7\u30eb\u300d\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\" width=\"580\" height=\"292\" class=\"size-large wp-image-2887\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/d5d61ab176d60f5f66b8f862e0346430-1024x516.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/d5d61ab176d60f5f66b8f862e0346430-300x151.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/d5d61ab176d60f5f66b8f862e0346430.png 1107w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2887\" class=\"wp-caption-text\">\u300c\u6b63\u89e3\u30e2\u30c7\u30eb\u300d\u306e\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/figcaption><\/figure>\n<figure id=\"attachment_2886\" aria-describedby=\"caption-attachment-2886\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/c10d498d83b37b1c69fc573bed1e944d.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/c10d498d83b37b1c69fc573bed1e944d-1024x479.png\" alt=\"\u5b8c\u6210\u3057\u305f\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3\" width=\"580\" height=\"271\" class=\"size-large wp-image-2886\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/c10d498d83b37b1c69fc573bed1e944d-1024x479.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/c10d498d83b37b1c69fc573bed1e944d-300x140.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/c10d498d83b37b1c69fc573bed1e944d.png 1138w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2886\" class=\"wp-caption-text\">\u5b8c\u6210\u3057\u305f\u30e2\u30c7\u30eb\u306e\u30b7\u30df\u30e5\u30fc\u30ec\u30fc\u30b7\u30e7\u30f3<\/figcaption><\/figure>\n<p>\u6570\u5f0f\u306e\u4fee\u6b63\u7b49\u3082\u542b\u3081\u305fChen2004\u30e2\u30c7\u30eb\u306e\u30c0\u30a4\u30a2\u30b0\u30e9\u30e0\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_2907\" aria-describedby=\"caption-attachment-2907\" style=\"width: 580px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/53bc17fb939873b602c2d721ba7525ce.png\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/53bc17fb939873b602c2d721ba7525ce-1024x648.png\" alt=\"Budding yeast cell cycle model (Chen2004, CellDesigner4.3 ver)\" width=\"580\" height=\"367\" class=\"size-large wp-image-2907\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/53bc17fb939873b602c2d721ba7525ce-1024x648.png 1024w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/53bc17fb939873b602c2d721ba7525ce-300x190.png 300w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2014\/03\/53bc17fb939873b602c2d721ba7525ce.png 1551w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/><\/a><figcaption id=\"caption-attachment-2907\" class=\"wp-caption-text\">Budding yeast cell cycle model (Chen2004, CellDesigner4.3 ver)<\/figcaption><\/figure>\n<h5>\u6700\u5f8c\u306b<\/h5>\n<p>\u306a\u304b\u306a\u304b\u5927\u5909\u306a\u4f5c\u696d\u3067\u3057\u305f\u304c\u3001\u9054\u6210\u611f\u306f\u975e\u5e38\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u304c\u3001\u300c\u30b5\u30a4\u30a8\u30f3\u30b9\u304b\u300d\u3068\u8a00\u308f\u308c\u308c\u3070\u82e5\u5e72\u7591\u554f\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u79c1\u81ea\u8eab\u3082\u304a\u3055\u3089\u3044\u3092\u542b\u3081\u3066\u3044\u308d\u3044\u308d\u3068\u52c9\u5f37\u306b\u306a\u308b\u3053\u3068\u304c\u591a\u304b\u3063\u305f\u3067\u3059\u3002\u6700\u521d\u3001\u300c\u5199\u7d4c\u300d\u3068\u8a00\u3044\u307e\u3057\u305f\u304c\u3001\u5f8c\u534a\u306e\u4f5c\u696d\u306f\u3080\u3057\u308d\u7cbe\u5de7\u306a\u6a21\u578b\u3092\u4f5c\u3063\u3066\u3044\u308b\u3088\u3046\u306a\u6c17\u6301\u3061\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u6a21\u578b\u3082\u6570\u7406\u30e2\u30c7\u30eb\u3082\u82f1\u8a9e\u3067\u306f\u300cmodel\u300d\u3067\u3059\u304b\u3089\u4f3c\u305f\u3088\u3046\u306a\u3082\u306e\u306a\u3093\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n<p>\u6700\u5f8c\u306b\u3044\u304f\u3064\u304b\u6c17\u306b\u306a\u3063\u305f\u70b9\u3092\u66f8\u3044\u3066\u7d42\u308f\u308a\u306b\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\uff08\uff11\uff09Chen2004\u30e2\u30c7\u30eb\u3067\u306f\u3001\u7279\u306b\u8981\u7d20\u306e\u91cf\u3092\u8a18\u8ff0\u3059\u308b\u5f0f\u306b\u7d71\u4e00\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u3053\u308d\u304c\u3042\u308a\u307e\u3059\u3002\u4ee5\u524d\u306e\u8ad6\u6587\u3067\u4f5c\u3089\u308c\u3066\u3044\u305f\u300c\u53e4\u3044\u300d\u90e8\u5206\u3068\u300c\u65b0\u3057\u3044\u90e8\u5206\u300d\u306e\u8a18\u8ff0\u306e\u30dd\u30ea\u30b7\u30fc\u304c\u7570\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u65b0\u3057\u3044\u90e8\u5206\u306f\u4ee3\u6570\u3067\u8981\u7d20\u306e\u91cf\u3092\u8a18\u8ff0\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n<p>\uff08\uff12\uff09\uff11\u306e\u300c\u4ee3\u6570\u300d\u304c\u3042\u308b\u305b\u3044\u3067\u3001CellDesigner4.3\u306e\u8a18\u8ff0\uff08\u30c0\u30a4\u30a2\u30b0\u30e9\u30e0\uff09\u3067\u306f\u9f5f\u9f6c\u304c\u751f\u3058\u3001\u30e2\u30c7\u30eb\u306b\u5fe0\u5b9f\u306b\u30c0\u30a4\u30a2\u30b0\u30e9\u30e0\u3092\u66f8\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002BioModels\u306e\u30e2\u30c7\u30eb\u3067\u306f\u305d\u306e\u9f5f\u9f6c\u304c\u751f\u3058\u308b\u305f\u3081\u304b\u3001CellDesigner4.3\u3067\u958b\u3044\u305f\u3042\u3068\u300c\u5225\u540d\u3067\u4fdd\u5b58\u300d\u3059\u308b\u3068\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u304c\u3046\u307e\u304f\u52d5\u304b\u306a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\uff08\uff13\uff09\u3053\u306e\u30e2\u30c7\u30eb\u306f\u3001CellDesigner4.3\u306eSimulation Control Panel\u306e\u6a19\u6e96\u306eSolver\uff08SOSlib\uff09\u3067\u306f\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u304d\u307e\u305b\u3093\u3002COPASI 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