{"id":3028,"date":"2015-03-20T11:08:22","date_gmt":"2015-03-20T02:08:22","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3028"},"modified":"2017-08-13T16:01:55","modified_gmt":"2017-08-13T07:01:55","slug":"%e3%82%b3%e3%83%89%e3%83%b3%e3%81%ae%e6%9c%80%e9%81%a9%e5%ba%a6%e3%81%afmrna%e3%81%ae%e5%ae%89%e5%ae%9a%e6%80%a7%e3%82%92%e6%b1%ba%e3%82%81%e3%82%8b%e4%b8%bb%e8%a6%81%e3%81%aa%e8%a6%81%e5%9b%a0","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3028","title":{"rendered":"\u30b3\u30c9\u30f3\u306e\u6700\u9069\u5ea6\u306fmRNA\u306e\u5b89\u5b9a\u6027\u3092\u6c7a\u3081\u308b\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3002"},"content":{"rendered":"

Codon optimality is a major determinant of mRNA stability.<\/a><\/p>\n

\n

Presnyak V, Alhusaini N, Chen YH, Martin S, Morris N, Kline N, Olson S, Weinberg D, Baker KE, Graveley BR, Coller J.<\/p>\n

Cell<\/span>. 2015 Mar 12;160(6):1111-24. doi: 10.1016\/j.cell.2015.02.029.\u00a0PMID:25768907<\/strong><\/p>\n

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\u3053\u306e\u8ad6\u6587\u3067\u3082\u65b0\u3057\u3044\u30c7\u30fc\u30bf\u3001\u300c\u7d30\u80de\u306e\u4e2d\u3067mRNA\u304c\u3069\u308c\u304f\u3089\u3044\u306e\u901f\u5ea6\u3067\u5206\u89e3\u3055\u308c\u3066\u3044\u308b\u304b\uff08mRNA\u306e\u534a\u6e1b\u671f\u30fb\u5b89\u5b9a\u6027\uff09\u300d\u3092\u3001\u8ee2\u5199\u3092\u6b62\u3081\u3066\u304b\u3089\u6bb5\u968e\u7684\u306bmRNA\u306e\u5b58\u5728\u91cf\u3092RNAseq\u3067\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\uff08\u3053\u308c\u307e\u3067\u3082\u3053\u306e\u3088\u3046\u306a\u89e3\u6790\u306f\u884c\u308f\u308c\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u4ee5\u524d\u306e\u89e3\u6790\u306f\u3001mRNA\u306e\u307f\u3092\u96c6\u3081\u308b\u305f\u3081\u306bpoly(A)\u3092\u4f7f\u3063\u3066\u3044\u305f\u3053\u3068\u3067\u3001\u7d50\u679c\u306b\u30d0\u30a4\u30a2\u30b9\u304c\u304b\u304b\u3063\u3066\u3044\u305f\u3088\u3046\u3067\u3059\uff09\u3002<\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u300cmRNA\u306e\u5b89\u5b9a\u6027\u3092\u6c7a\u3081\u3066\u3044\u308b\u306e\u306f\u3001\u540c\u7fa9\u30b3\u30c9\u30f3\u306e\u4f7f\u308f\u308c\u65b9\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u3001\u975e\u5e38\u306b\u9762\u767d\u3044\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u300c\u534a\u6e1b\u671f\u306e\u9577\u3044mRNA\u306f\u3001\u305f\u304f\u3055\u3093\u5b58\u5728\u3059\u308btRNA\u306e\u30b3\u30c9\u30f3\uff08\u3057\u3070\u3057\u3070\u300c\u6700\u9069\u30b3\u30c9\u30f3\uff08Optimal codon\uff09\u300d\u3068\u547c\u3070\u308c\u308b\uff09\u3092\u597d\u3093\u3067\u4f7f\u3044\u3001\u534a\u6e1b\u671f\u304c\u77ed\u3044mRNA\u306f\u3001\u6700\u9069\u3067\u306a\u3044\uff08non-optimal codon\uff09\u3092\u597d\u3093\u3067\u4f7f\u3063\u3066\u3044\u308b\u300d\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

mRNA\u306e\u5b89\u5b9a\u6027\u3092\u6c7a\u3081\u308b\u8981\u56e0\u306f\u3001\u3053\u308c\u307e\u3067\u306f\u975e\u7ffb\u8a33\u9818\u57df\u3001\u7279\u306b3\u2019\u672b\u7aef\u306e\u975e\u7ffb\u8a33\u9818\u57df\u3068\u305d\u3053\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4f5c\u7528\u306b\u3088\u308b\u3082\u306e\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\uff08\u79c1\u3082\u305d\u3046\u601d\u3063\u3066\u3044\u307e\u3057\u305f\uff09\u3002\u3067\u3059\u304c\u3001\u975e\u7ffb\u8a33\u9818\u57df\u3067\u8aac\u660e\u3067\u304d\u308b\u306e\u306f\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u306e\u307f\u3067\u3001\u5927\u534a\u306e\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u306f\u8b0e\u3060\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u305d\u308c\u304c\u3001\u30b3\u30c9\u30f3\u4f7f\u308f\u308c\u65b9\u3067\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u8aac\u660e\u304c\u3064\u3044\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3053\u308c\u306f\u307e\u3055\u306b\u6b74\u53f2\u306b\u6b8b\u308b\u767a\u898b\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u80cc\u666f\u3068\u306a\u3063\u3066\u3044\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u3053\u308c\u304b\u3089\u3060\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u306e\u9032\u884c\u901f\u5ea6\u3068RNA\u5206\u89e3\u9175\u7d20\u306emRNA\u3078\u306e\u30a2\u30af\u30bb\u30b9\u3057\u3084\u3059\u3055\u3067\u8aac\u660e\u3067\u304d\u308b\u6c17\u304c\u3057\u307e\u3059\u3002<\/p>\n

\u300c\u30b3\u30c9\u30f3\u306e\u6700\u9069\u5316\u300d\u306f\u3001\u7ffb\u8a33\u52b9\u7387\u3092\u4e0a\u3052\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3066mRNA\u306e\u534a\u6e1b\u671f\u3082\u9577\u304f\u3055\u305b\u308b\u52b9\u679c\u304c\u3042\u3063\u3066\u3001\u6700\u7d42\u7684\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u91cf\u3092\u5927\u304d\u304f\u5897\u3084\u3059\u7d50\u679c\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u3059\u306d\u3002\u30fb\u30fb\u30fb\u30b3\u30c9\u30f3\u4fae\u308a\u304c\u305f\u3057\u3002<\/p>\n

\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Codon optimalit…<\/p>\n","protected":false},"author":3,"featured_media":3493,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[10,22,8,9],"tags":[],"class_list":["post-3028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-10","category-22","category-8","category-9"],"_links":{"self":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3028"}],"version-history":[{"count":23,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3028\/revisions"}],"predecessor-version":[{"id":3051,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3028\/revisions\/3051"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/media\/3493"}],"wp:attachment":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3028"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3028"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}