{"id":3712,"date":"2018-03-05T12:50:09","date_gmt":"2018-03-05T03:50:09","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3712"},"modified":"2018-03-05T17:44:19","modified_gmt":"2018-03-05T08:44:19","slug":"srp%e3%81%af%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%81%ae%e8%bc%b8%e9%80%81%e3%81%ae%e5%8a%b9%e7%8e%87%e3%81%a8%e7%89%b9%e7%95%b0%e6%80%a7%e3%82%92%e6%b1%ba%e3%82%81%e3%82%8b","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3712","title":{"rendered":"SRP\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u8f38\u9001\u306e\u52b9\u7387\u3068\u7279\u7570\u6027\u3092\u6c7a\u3081\u308b"},"content":{"rendered":"<p class=\"title\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29348368\">Defining the physiological role of SRP in protein-targeting efficiency and specificity.<\/a><\/p>\n<p class=\"title\">Costa EA, Subramanian K, Nunnari J, Weissman JS.\u00a0<span class=\"jrnl\" title=\"Science (New York, N.Y.)\">Science<\/span>. 2018 Feb 9;359(6376):689-692. doi: 10.1126\/science.aar3607. Epub 2018 Jan 18. PMID:29348368<\/p>\n<p>\u7814\u7a76\u5ba4\u306eHaku\u3055\u3093\u304c\u30c7\u30d3\u30e5\u30fc\u6226\u3067\u7d39\u4ecb\u3057\u305f\u8ad6\u6587\u3067\u3059\u3002<\/p>\n<p>\u771f\u6838\u7d30\u80de\u306f\u3001\u7d30\u80de\u5185\u304c\u7d30\u80de\u5c0f\u5668\u5b98\u306b\u3088\u3063\u3066\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u305e\u308c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u3061\u3083\u3093\u3068\u76ee\u7684\u306e\u30b3\u30f3\u30d1\u30fc\u30c8\u30e1\u30f3\u30c8\u306b\u904b\u3070\u308c\u3066\u6a5f\u80fd\u3057\u3066\u304f\u308c\u306a\u3044\u3068\u56f0\u308b\u306e\u3067\u3001\u305d\u306e\u305f\u3081\u306b\u8907\u96d1\u3060\u3051\u3069\u3088\u304f\u3067\u304d\u305f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u9032\u5316\u3055\u305b\u3066\u304d\u307e\u3057\u305f\u3002\u771f\u6838\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\uff08\u7ffb\u8a33\uff09\u306f\u3001\u307b\u307c\u3059\u3079\u3066\u7d30\u80de\u8cea\u3067\u884c\u308f\u308c\u3001\u305d\u306e\u3046\u306130\uff05\u4ee5\u4e0a\u306e\u3082\u306e\u306f\u3001\u7d30\u80de\u8cea\u306b\u306f\u3068\u3069\u307e\u3089\u305a\u5c0f\u80de\u4f53\uff08ER\uff09\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u904b\u3070\u308c\u307e\u3059\u3002<\/p>\n<p>ER\u3078\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8f38\u9001\uff08\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\uff09\u306f\u3001\u300c\u30b7\u30b0\u30ca\u30eb\u8a8d\u8b58\u7c92\u5b50\uff08Signal Recognition Particle: SRP\uff09\u304c\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u304b\u3089\u51fa\u3066\u304f\u308b\u7ffb\u8a33\u9014\u4e2d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u914d\u5217\uff08\u8f38\u9001\u30b7\u30b0\u30ca\u30eb\uff09\u3092\u8a8d\u8b58\u3057\u3066\u7d50\u5408\u3057\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u3092ER\u8868\u9762\u306b\u9023\u308c\u3066\u3044\u304d\u3001\u7ffb\u8a33\u3057\u306a\u304c\u3089ER\u5185\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u8f38\u9001\u3055\u308c\u308b\u300d\u3068\u3044\u3046\u306e\u304c\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u53e4\u5178\u7684\u306b\u77e5\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002\u3061\u306a\u307f\u306b\u3053\u308c\u306f\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u7d30\u80de\u8868\u9762\uff08\u30da\u30ea\u30d7\u30e9\u30ba\u30e0\uff09\u3078\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8f38\u9001\u306b\u3082\u4f7f\u308f\u308c\u308b\u5171\u901a\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3059\u3002<\/p>\n<p>\u305f\u3060\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\u306f\u5b9f\u306f\u305d\u308c\u307b\u3069\u5358\u7d14\u3067\u306f\u306a\u304f\u3001SRP\u306b\u4f9d\u5b58\u3059\u308b\u3082\u306e\uff08\u7ffb\u8a33\u3057\u306a\u304c\u3089\u8f38\u9001\u3059\u308b\u3082\u306e\uff09\u306e\u4ed6\u306b\u3001SRP\u306b\u4f9d\u5b58\u3057\u306a\u3044\u3082\u306e\uff08\u7ffb\u8a33\u304c\u7d42\u308f\u3063\u305f\u5f8c\u306b\u8f38\u9001\u3059\u308b\u3082\u306e\uff09\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u3055\u3089\u306b\u3069\u306e\u3088\u3046\u306a\u914d\u5217\u30fb\u6027\u8cea\u3092\u6301\u3063\u305f\u3082\u306e\u304c\u305d\u308c\u305e\u308c\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u3063\u3066\u8f38\u9001\u3055\u308c\u308b\u306e\u304b\u3001\u305d\u306e\u8a73\u7d30\u304c\u6700\u8fd1\u306b\u306a\u3063\u3066\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7279\u306b\u6700\u8fd1\u3001\u7ffb\u8a33\u3055\u308c\u306a\u304c\u3089ER\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4e00\u7db2\u6253\u5c3d\u306b\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u9769\u65b0\u7684\u306a\u6280\u8853\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u308c\u304c\u3001\u300cProximity Specific Ribosomal Profiling\uff08\u8fd1\u63a5\u7279\u7570\u7684\u30ea\u30dc\u30bd\u30fc\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\uff09\u300d\u3067\u3059\u3002\u30ea\u30dc\u30bd\u30fc\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u306f\u3001\u30ea\u30dc\u30bd\u30fc\u30e0\u304c\u565b\u307f\u8fbc\u3093\u3060mRNA\u306e\u914d\u5217\u306e\u51fa\u73fe\u983b\u5ea6\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u300c\u7d30\u80de\u306e\u4e2d\u3067\u3001\u3069\u306emRNA\u306e\u3069\u3053\u306e\u914d\u5217\u304c\u3069\u308c\u304f\u3089\u3044\u7ffb\u8a33\u3055\u308c\u3066\u3044\u308b\u304b\u300d\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6280\u8853\u3067\u3059\u3002\u4ee5\u524d\u3053\u306e\u30d6\u30ed\u30b0\u3067\u3082\u3001<a href=\"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=2939\" target=\"_blank\" rel=\"noopener\">\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5408\u6210\u901f\u5ea6\u306e\u7d76\u5bfe\u5b9a\u91cf\u3092\u53ef\u80fd\u306b\u3057\u305f\u6280\u8853\u300d\u3068\u3057\u3066\u7d39\u4ecb\u3057\u307e\u3057\u305f<\/a>\u3002<\/p>\n<p>Proximity Specific &#8230;\u306f\u3001\u3053\u308c\u3092\u3055\u3089\u306b\u6539\u826f\u3057\u3001ER\u8868\u9762\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u8868\u9762\u306b\u3042\u308b\u30ea\u30dc\u30bd\u30fc\u30e0\u304c\u7ffb\u8a33\u3057\u3066\u3044\u308bmRNA\u3092\u540c\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u307e\u305a\u306fER\u306b\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\u3055\u308c\u308b\u4e00\u7fa4\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4eca\u56de\u7b46\u8005\u3089\u306f\u3055\u3089\u306b\u4e00\u6b69\u8e0f\u307f\u8fbc\u3093\u3067\u3001SRP\u4f9d\u5b58\u7684\u306b\u30bf\u30fc\u30b2\u30c3\u30c6\u30a3\u30f3\u30b0\u3055\u308c\u308b\u3082\u306e\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002SRP\u304c\u306a\u3044\u3068\u7d30\u80de\u306f\u751f\u304d\u3089\u308c\u306a\u3044\u306e\u3067\u3001\u7b46\u8005\u3089\u306fSRP\u3092\u6761\u4ef6\u4f9d\u5b58\u7684\u306b\u5206\u89e3\u3059\u308b\u3068\u3044\u3046\u4f5c\u6226\u3092\u53d6\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u305f\u3081\u3001<a href=\"https:\/\/www.nig.ac.jp\/nig\/ja\/research\/organization-top\/laboratories\/kanemaki\" target=\"_blank\" 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the 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