{"id":3720,"date":"2018-03-15T13:17:49","date_gmt":"2018-03-15T04:17:49","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3720"},"modified":"2018-03-15T13:25:52","modified_gmt":"2018-03-15T04:25:52","slug":"%e3%83%87%e3%82%a3%e3%83%bc%e3%83%97%e3%83%a9%e3%83%bc%e3%83%8b%e3%83%b3%e3%82%b0%e3%81%ab%e3%82%88%e3%82%8b%e7%b4%b0%e8%83%9e%e3%81%ae%e9%9a%8e%e5%b1%a4%e7%9a%84%e6%a7%8b%e9%80%a0%e3%82%84%e6%a9%9f","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3720","title":{"rendered":"\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u306b\u3088\u308b\u7d30\u80de\u306e\u968e\u5c64\u7684\u69cb\u9020\u3084\u6a5f\u80fd\u306e\u30e2\u30c7\u30eb\u5316"},"content":{"rendered":"

Using deep learning to model the hierarchical structure and function of a cell.<\/a><\/p>\n

\n

Ma J, Yu MK, Fong S, Ono K, Sage E, Demchak B, Sharan R, Ideker T.\u00a0Nat Methods<\/span>. 2018 Mar 5. doi: 10.1038\/nmeth.4627. PMID:29505029<\/span><\/p>\n

\u300c\u907a\u4f1d\u5b50\u578b\u304b\u3089\u8868\u73fe\u578b\u3092\u3059\u3079\u3066\u8aac\u660e\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u300d\u306e\u306f\u3001\u907a\u4f1d\u5b66\u30fb\u30b7\u30b9\u30c6\u30e0\u751f\u7269\u5b66\u306e\u7a76\u6975\u306e\u30b4\u30fc\u30eb\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3058\u3083\u3042\u3069\u3046\u306a\u3063\u305f\u3089\u3059\u3079\u3066\u8aac\u660e\u3067\u304d\u305f\u3053\u3068\u306b\u306a\u308b\u306e\u304b\uff1f \u79c1\u306f\u305d\u306e\u4e00\u3064\u306e\u65b9\u6cd5\u304c\u3001\u300c\u5168\u7d30\u80de\u306e\u6570\u7406\u30e2\u30c7\u30eb\u5316\u300d\u3060\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u907a\u4f1d\u5b50\u578b\u3092\u5909\u3048\u305f\u3089\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u53cd\u6620\u3055\u308c\u308b\u304b\u3092\u3001\u305d\u306e\u30e2\u30c7\u30eb\u304c\u518d\u73fe\u3059\u308b\u3002\u305d\u308c\u304c\u5b9f\u969b\u306e\u7d30\u80de\u3067\u8d77\u304d\u308b\u3053\u3068\u3068\u5b8c\u5168\u306b\u4e00\u81f4\u3057\u305f\u3089\u3001\u305d\u306e\u3068\u304d\u4e0a\u8a18\u306e\u30b4\u30fc\u30eb\u306b\u9054\u3057\u305f\u3068\u8a00\u3063\u3066\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u3058\u3083\u3042\u305d\u306e\u6570\u7406\u30e2\u30c7\u30eb\u5316\u306e\u65b9\u6cd5\u306f\uff1f \uff11\u3064\u306e\u3084\u308a\u65b9\u306f\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u3059\u3002\u7d30\u80de\u5185\u3067\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3001\u4f8b\u3048\u3070\u8ee2\u5199\u3084\u7ffb\u8a33\u3001\u8907\u88fd\u306a\u3069\u3092\u306a\u308b\u3079\u304f\u5206\u304b\u3063\u3066\u3044\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u307e\u307e\u518d\u69cb\u7bc9\u3057\u3066\u52d5\u304b\u3059\u3002\u4ee5\u524d\u3053\u306e\u30d6\u30ed\u30b0\u3067\u3082\u7d39\u4ecb\u3057\u305f\u3001\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u306e\u5168\u7d30\u80de\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/a>\u304c\u305d\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u4e00\u3064\u3067\u3059\u3002<\/p>\n

\u3082\u3046\u4e00\u3064\u3001\u9593\u9055\u3044\u306a\u304f\u3067\u304d\u308b\u3068\u601d\u308f\u308c\u3066\u3044\u308b\u3082\u306e\uff08\u79c1\u304c\u601d\u3063\u3066\u3044\u305f\u3082\u306e\uff09\u304c\u4eba\u5de5\u77e5\u80fd\u306b\u3088\u308b\u5168\u7d30\u80de\u306e\u30e2\u30c7\u30eb\u3002\u3053\u3061\u3089\u306f\u304a\u305d\u3089\u304f\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u518d\u69cb\u7bc9\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u300c\u77e5\u8b58\u3092\u518d\u69cb\u7bc9\u3059\u308b\u30e2\u30c7\u30eb\u300d\u306b\u306a\u308b\u3068\u4e88\u60f3\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3084\u3063\u3071\u308a\u3084\u3063\u3066\u3044\u308b\u4eba\u306f\u3044\u3066\u3001\u300c\u9042\u306b\uff08\u3068\u8a00\u3046\u304b\u3001\u3082\u3046\uff1f\uff09\u305d\u306e\u30e2\u30c7\u30eb\u304c\u767a\u8868\u3055\u308c\u305f\uff01\u300d\u3001\u3068\u3053\u306e\u8ad6\u6587\u306e\u30bf\u30a4\u30c8\u30eb\u3092\u898b\u3066\u79c1\u306f\u601d\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u305f\u3060\u3001\u5b9f\u969b\u306b\u306f\u3053\u306e\u30e2\u30c7\u30eb\u306e\u300c\u30a6\u30ea\u300d\u306f\u305d\u3046\u3044\u3046\u3053\u3068\u3067\u306f\u306a\u304b\u3063\u305f\u3088\u3046\u3067\u3059\u3057\u3001\u3053\u306e\u30e2\u30c7\u30eb\u306e\u5229\u7528\u4fa1\u5024\u306f\u307e\u3060\u9650\u3089\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u601d\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u524d\u7f6e\u304d\u306f\u3053\u306e\u3078\u3093\u3067\u3002<\/p>\n

\u3053\u306e\u8ad6\u6587\u306e\u4e3b\u65e8\u306f\u3001\u300cGene Ontology\u3092\u30d9\u30fc\u30b9\u306b\u3057\u3066\u4f5c\u3063\u305f\u968e\u5c64\u7684\u306a\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u3001\u907a\u4f1d\u5b50\u7834\u58ca\u30fb\u4e8c\u91cd\u907a\u4f1d\u5b50\u7834\u58ca\u306e\u8868\u73fe\u578b\uff08\u5897\u6b96\uff09\u3092\u3082\u3068\u306b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff08\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\uff09\u3057\u305f\u3089\u3001\u3068\u3066\u3082\u4e88\u6e2c\u7cbe\u5ea6\u306e\u9ad8\u3044\u30e2\u30c7\u30eb\u304c\u51fa\u6765\u305f\u3002\u3057\u304b\u3082\u3001\u524d\u60c5\u5831\u306a\u3057\u3067\u4f5c\u3063\u305f\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3067\u306f\u3067\u304d\u306a\u304b\u3063\u305f\u3001\u30e2\u30c7\u30eb\u306e\u4e2d\u3067\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u4eba\u9593\u306b\u898b\u3048\u308b\u30e2\u30c7\u30eb\u306b\u306a\u3063\u305f\u3002\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n

Gene Ontology\u306f\u3001\u6587\u732e\u60c5\u5831\uff08\u77e5\u8b58\uff09\u3092\u3082\u3068\u306b\u3064\u304f\u3089\u308c\u305f\u7d30\u80de\u30fb\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u8aac\u660e\u3059\u308b\u305f\u3081\u306e\u8a9e\u5f59\u3067\u3001\u305d\u308c\u81ea\u8eab\u304c\u968e\u5c64\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u968e\u5c64\u69cb\u9020\u3092\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3067\u518d\u69cb\u7bc9\u3057\u3066\u30e2\u30c7\u30eb\u5316\u3059\u308b\u3068\u3044\u3046\u306e\u304c\u3001\u306a\u308b\u307b\u3069\u65ac\u65b0\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u30e2\u30c7\u30eb\u306f\u307e\u3055\u306b\u4e88\u60f3\u3057\u3066\u3044\u305f\u3088\u3046\u306a\u300c\u77e5\u8b58\u3092\u518d\u69cb\u7bc9\u3059\u308b\u30e2\u30c7\u30eb\u300d\u3068\u3044\u3046\u4e8b\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u305f\u3060\u3001\u5b9f\u969b\u306b\u306f\u305d\u306e\u8a66\u307f\u306f\u3053\u306e\u8ad6\u6587\u304c\u521d\u3081\u3066\u3067\u306f\u306a\u304f\u3001\u540c\u3058\u7b46\u8005\u3089\u306e\uff11\u3064\u524d\u306e\u8ad6\u6587\uff08\u4ee5\u4e0b\uff09\u3067\u884c\u308f\u308c\u307e\u3057\u305f\uff08\u3053\u306e\u8ad6\u6587\u3001\u79c1\u306f\u898b\u9003\u3057\u3066\u3044\u307e\u3057\u305f\uff09\u3002<\/p>\n

Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems.<\/a><\/p>\n

\n

Yu MK, Kramer M, Dutkowski J, Srivas R, Licon K, Kreisberg J, Ng CT, Krogan N, Sharan R, Ideker T.\u00a0Cell Syst<\/span>. 2016 Feb 24;2(2):77-88.\u00a0PMID:26949740<\/span><\/p>\n<\/div>\n

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\u00a0\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u300cGene Ontology\u3092\u3082\u3068\u306b\u968e\u5c64\u69cb\u9020\u3092\u6301\u3064\u30e2\u30c7\u30eb\uff08\u3053\u306e\u6642\u306f\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3067\u306f\u306a\u304b\u3063\u305f\uff09\u3092\u3064\u304f\u308a\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3057\u305f\u3089\u3001\u4eca\u307e\u3067\u306e\u6570\u7406\u30e2\u30c7\u30eb\u3088\u308a\u3082\u4e88\u6e2c\u7cbe\u5ea6\u304c\u9ad8\u304b\u3063\u305f\u300d\u3053\u3068\u3092\u793a\u3057\u3066\u307e\u3059\u3002\u300c\uff08Gene Ongology\u3068\u3044\u3046\uff09\u8a9e\u5f59\u3092\u6570\u5b66\u7684\u306b\u9023\u95a2\u3055\u305b\u305f\u3089\u5168\u7d30\u80de\u30e2\u30c7\u30eb\u306b\u306a\u308b\u300d\u306a\u3093\u3066\u3001\u306a\u3093\u3066\u3059\u3054\u3044\u767a\u898b\u306a\u3093\u3060\u308d\u3046\u3068\u79c1\u306f\u601d\u3044\u307e\u3057\u305f\u3002<\/dl>\n
\u3067\u3001\u3053\u306e\u8ad6\u6587\u3092\u3046\u3051\u3066\u4eca\u56de\u306e\u8ad6\u6587\u3067\u306f\u3053\u306e\u968e\u5c64\u30e2\u30c7\u30eb\u3092\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u5316\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u3055\u3089\u306b\u4e88\u6e2c\u7cbe\u5ea6\u304c\u4e0a\u304c\u3063\u305f\uff08\u7b46\u8005\u3089\u306f\u3001\u300c\u5b9f\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u308b\u306e\u3068\u540c\u3058\u304f\u3089\u3044\u306e\u7cbe\u5ea6\u300d\u3068\u8a00\u3063\u3066\u3044\u307e\u3059\uff09\u3002\u5b9f\u969b\u306b\u306f\u3001Ontology\u306b\u3088\u308b\u62d8\u675f\u6761\u4ef6\u3092\u3064\u3051\u305a\u306b\u4f5c\u3063\u305f\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u30c7\u30a3\u30fc\u30d7\u30e9\u30fc\u30cb\u30f3\u30b0\u3057\u3066\u3082\u540c\u3058\u3088\u3046\u306a\u7cbe\u5ea6\u306e\u30e2\u30c7\u30eb\u306f\u3067\u304d\u308b\u3088\u3046\u3067\u3059\u3002\u305f\u3060\u3001\u305d\u306e\u5834\u5408\u306b\u306f\u305d\u306e\u30e2\u30c7\u30eb\u306e\u4e88\u6e2c\u306e\u4e2d\u8eab\u306b\u3064\u3044\u3066\u751f\u7269\u5b66\u7684\u306a\u89e3\u91c8\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3002\u3060\u304b\u3089\u3001\u4eca\u56de\u306e\u300c\u898b\u3048\u308b\u30cb\u30e5\u30fc\u30e9\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08VNN\uff09\u300d\u306f\u751f\u7269\u5b66\u7684\u306b\u5f79\u306b\u7acb\u3064\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u308f\u3051\u3067\u3059\u3002<\/dl>\n
\u4e00\u65b9\u3067\u3001\u3059\u3067\u306b\u5206\u304b\u3063\u3066\u3044\u308b\u77e5\u8b58\u3092\u3082\u3068\u306b\u4f5c\u3089\u308c\u305fGene Ontology\u3092\u3082\u3068\u306b\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u4f5c\u3063\u3066\u3044\u3066\u3001\u304b\u3064\u5185\u90e8\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u306a\u3044\u30e2\u30c7\u30eb\u306a\u306e\u3067\u3001\u3053\u3053\u304b\u3089\u3069\u306e\u3088\u3046\u306a\u65b0\u3057\u3044\u751f\u7269\u5b66\u7684\u304c\u306a\u3055\u308c\u308b\u306e\u304b\u3001\u3061\u3087\u3063\u3068\u306f\u3063\u304d\u308a\u3057\u307e\u305b\u3093\u3002\u30e2\u30c7\u30eb\u69cb\u7bc9\u306e\uff11\u3064\u306e\u76ee\u7684\u306f\u3001\u5206\u304b\u3063\u3066\u3044\u308b\u3053\u3068\u3068\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u306f\u3063\u304d\u308a\u3055\u305b\u3066\u3001\u65b0\u3057\u3044\u5b9f\u9a13\u306e\u30d2\u30f3\u30c8\u3092\u4e0e\u3048\u308b\u3053\u3068\u306b\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u3053\u306e\u30e2\u30c7\u30eb\u306f\u3069\u306e\u3088\u3046\u306a\u30d2\u30f3\u30c8\u3092\u4e0e\u3048\u3066\u304f\u308c\u308b\u306e\u304b\u3001\u30a4\u30e1\u30fc\u30b8\u304c\u308f\u304b\u306a\u3044\u306e\u3067\u3059\u3002\u30e2\u30c7\u30eb\u3092\u5229\u7528\u3067\u304d\u308b\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\uff08http:\/\/d-cell.ucsd.edu\/\uff09\u3082\u3042\u308a\u3001\u79c1\u3082\u5c11\u3057\u52d5\u304b\u3057\u3066\u307f\u307e\u3057\u305f\u304c\u3001\u3059\u3050\u306b\u4f7f\u3048\u308b\u3068\u3044\u3046\u5370\u8c61\u306f\u53d7\u3051\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/dl>\n
\u307e\u3042\u3001\u3053\u308c\u306f\u65b0\u3057\u3044\u30e2\u30c7\u30eb\u69cb\u7bc9\u306e\u65b9\u6cd5\u8ad6\u306e\u30b9\u30bf\u30fc\u30c8\u3067\u3042\u308a\u3001\u3053\u308c\u304c\u5b8c\u6210\u578b\u3068\u3044\u3046\u3053\u3068\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u3053\u308c\u304b\u3089\u3053\u306e\u30bf\u30a4\u30d7\u306e\u30e2\u30c7\u30eb\u304c\u3069\u3046\u767a\u5c55\u3057\u3066\u3044\u304f\u306e\u304b\u3001\u3069\u3046\u7814\u7a76\u8005\u306b\u4f7f\u308f\u308c\u3066\u3044\u304f\u306e\u304b\u3001\u671f\u5f85\u3057\u306a\u304c\u3089\u30d5\u30a9\u30ed\u30fc\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/dl>\n
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