{"id":3843,"date":"2018-12-21T18:20:25","date_gmt":"2018-12-21T09:20:25","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3843"},"modified":"2018-12-29T15:13:15","modified_gmt":"2018-12-29T06:13:15","slug":"%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%81%ae%e9%80%b2%e5%8c%96%e3%81%ab%e5%90%91%e3%81%91%e3%81%9f%e9%85%b5%e6%af%8d%e3%81%ae%e7%b4%b0%e8%83%9e%e5%86%85%e5%85%b1%e7%94%9f","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3843","title":{"rendered":"\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9032\u5316\u306b\u5411\u3051\u305f\u9175\u6bcd\u306e\u7d30\u80de\u5185\u5171\u751f\u4f53\u306e\u4f5c\u6210"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30373839\">Engineering yeast endosymbionts as a step toward the evolution of mitochondria.&nbsp;<\/a>Mehta AP, Supekova L, Chen JH, Pestonjamasp K, Webster P, Ko Y, Henderson SC, McDermott G, Supek F, Schultz PG. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):11796-11801. <g class=\"gr_ gr_14 gr-alert gr_spell gr_inline_cards gr_run_anim ContextualSpelling\" id=\"14\" data-gr-id=\"14\">doi<\/g>: 10.1073\/pnas.1813143115. Epub 2018 Oct 29.PMID:&nbsp;30373839<\/p>\n\n\n\n<p>\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u3068\u3057\u3066\u6709\u540d\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u3001\u3082\u3068\u3082\u3068\u306f\u771f\u6838\u7d30\u80de\u306e\u7956\u5148\u7d30\u80de\u306b\u6f5c\u308a\u8fbc\u3093\u3067\u5171\u751f\u3092\u59cb\u3081\u305f\u30d0\u30af\u30c6\u30ea\u30a2\u306b\u7531\u6765\u3059\u308b\u3068\u3044\u3046\u300c\u7d30\u80de\u5185\u5171\u751f\u8aac\u300d\u306f\u3068\u3066\u3082\u30ed\u30de\u30f3\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u300c\u8aac\u300d\u3068\u306f\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304c\u6301\u3063\u3066\u3044\u308bDNA\u3084\u305d\u3053\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u898b\u308b\u9650\u308a\u3001\u307b\u307c\u78ba\u304b\u3067\u3042\u308b\u3068\u8a00\u3063\u3066\u3044\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u300c\u6f5c\u308a\u8fbc\u3093\u3067\u5171\u751f\u3092\u59cb\u3081\u305f\u3068\u3053\u308d\u300d\u3092\u5b9f\u9a13\u5ba4\u3067\u518d\u73fe\u3057\u3066\u3084\u308d\u3046\u3068\u3044\u3046\u3001\u3068\u3066\u3082\u5927\u80c6\u306a\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5927\u80c6\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u5171\u751f\u3092\u6210\u7acb\u3055\u305b\u308b\u30b9\u30ad\u30fc\u30e0\u306f\u305d\u3046\u96e3\u3057\u305d\u3046\u306b\u306f\u601d\u3044\u307e\u305b\u3093\u3002\u5927\u62b5\u306e\u4eba\u304c\u601d\u3044\u3064\u304d\u305d\u3046\u306a\u3084\u308a\u65b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3064\u307e\u308a\u3001\uff11\uff09\u547c\u5438\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u771f\u6838\u7d30\u80de\u304b\u3089\u53d6\u308a\u9664\u304d\uff08\u3059\u308b\u3068\u9178\u7d20\u547c\u5438\u304c\u3067\u304d\u306a\u304f\u306a\u308b\uff09\u3001\uff12\uff09\u305d\u306e\u4ee3\u308f\u308a\u306b\u9178\u7d20\u547c\u5438\u3092\u3057\u3066ATP\u3092\u4f9b\u7d66\u3059\u308b\u30d0\u30af\u30c6\u30ea\u30a2\u3092\u7d30\u80de\u306b\u3044\u308c\u3066\u3084\u308a\u3001\uff13\uff09\u305d\u306e\u30d0\u30af\u30c6\u30ea\u30a2\u81ea\u8eab\u306f\u5bbf\u4e3b\u306e\u7d30\u80de\u304b\u3089\u5897\u6b96\u306b\u5fc5\u8981\u306a\u6804\u990a\u7d20\u3092\u4f9b\u7d66\u3055\u308c\u308b\u3001\u3068\u3044\u3046\u72b6\u614b\u3092\u6210\u7acb\u3055\u305b\u308c\u3070\u826f\u3044\u3002\u3067\u3059\u304c\u3053\u306e\u305f\u3081\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u30c8\u30ea\u30c3\u30af\u3092\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u306b\u4ed5\u8fbc\u3093\u3067\u3084\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30c8\u30ea\u30c3\u30af\u3092\u6210\u7acb\u3055\u305b\u308b\u305f\u3081\u306b\u8457\u8005\u3089\u304c\u9078\u3093\u3060\u306e\u306f\u3001\u51fa\u82bd\u9175\u6bcd\uff08Saccharomyces cereviaie\uff09\u3068\u5927\u8178\u83cc\uff08Escherichia coli\uff09\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\uff11\u306b\u95a2\u3057\u3066\u3002\u5927\u62b5\u306e\u5834\u5408\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5931\u308f\u305b\u308b\u3068\u7d30\u80de\u306f\u6b7b\u3093\u3067\u3057\u307e\u3044\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u51fa\u82bd\u9175\u6bcd\u3067\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u547c\u5438\u6a5f\u80fd\u304c\u6b20\u640d\u3057\u3066\u3082\uff08\u03c10\u682a\uff09\u3001\u767a\u9175\u306b\u3088\u3063\u3066\u751f\u304d\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u767a\u9175\u3067\u5927\u91cf\u306eATP\u3092\u7523\u751f\u3067\u304d\u308b\u305f\u3081\u3067\u3057\u3087\u3046\u3002\u305f\u3060\u3053\u306e\u682a\u3001\u767a\u9175\u306b\u4f7f\u3048\u306a\u3044\u70ad\u7d20\u6e90\u3057\u304b\u306a\u3044\u57f9\u5730\uff08\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u57f9\u5730\uff09\u3067\u306f\u5897\u6b96\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u3067\u3059\u304b\u3089\u3001\u57f9\u5730\u306e\u5207\u308a\u66ff\u3048\u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5fc5\u8981\u6027\u3092\u5207\u308a\u66ff\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\uff12\u306b\u95a2\u3057\u3066\u3002\u5f53\u7136\u306a\u304c\u3089\u5927\u8178\u83cc\u306f\u81ea\u5206\u3067\u4f5c\u3063\u305fATP\u306f\u81ea\u5206\u3067\u4f7f\u3044\u305f\u3044\u306e\u3067\u3001\u7d30\u80de\u306e\u5916\uff08\u3053\u306e\u5834\u5408\u306b\u306f\u9175\u6bcd\u7d30\u80de\u306e\u4e2d\uff09\u306b\u653e\u51fa\u3057\u3066\u304f\u308c\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001\u7b46\u8005\u3089\u306f\u7d30\u80de\u5185\u306b\u4f4f\u3080\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u3082\u3064ADP\u3068ATP\u306e\u4ea4\u63db\u53cd\u5fdc\u3092\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\uff08ADP\/ATP translocase\uff09\u3092\u5927\u8178\u83cc\u306b\u4f5c\u3089\u305b\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\uff13\u306b\u95a2\u3057\u3066\u3002\u3053\u306e\u5927\u8178\u83cc\u306f\u30d3\u30bf\u30df\u30f3B1\uff08\u30c1\u30a2\u30df\u30f3\uff09\u306e\u5408\u6210\u9175\u7d20\u306b\u5909\u7570\u3092\u3082\u3061\u81ea\u5206\u3067\u306f\u30c1\u30a2\u30df\u30f3\u304c\u4f5c\u308c\u306a\u3044\u305f\u3081\u9175\u6bcd\u306b\u4f9b\u7d66\u3057\u3066\u3082\u3089\u3046\u5fc5\u8981\u304c\u3042\u308b\u3001\u3068\u3044\u3046\u72b6\u6cc1\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u5171\u751f\u95a2\u4fc2\u3092\u6210\u7acb\u3055\u305b\u308b\u305f\u3081\u306e\u6761\u4ef6\u306f\u6574\u3063\u305f\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u9175\u6bcd\u3068\u5927\u8178\u83cc\u3092\u878d\u5408\u3055\u305b\u307e\u3059\u3002\u4ee5\u524d\u306e\u7814\u7a76\u3067\u3001\u9175\u6bcd\u7d30\u80de\u306b\u5916\u90e8\u304b\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5c0e\u5165\u3059\u308b\u300cpolyethylene glycol (PEG)-induced fusion\u300d\u3068\u3044\u3046\u65b9\u6cd5\u304c\u78ba\u7acb\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u4f7f\u3063\u3066\u4e8c\u3064\u306e\u7d30\u80de\u3092\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u3053\u306e\u30d5\u30e5\u30fc\u30b8\u30e7\u30f3\u7d30\u80de\u3092\u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u57f9\u5730\u306b\u6492\u3044\u3066\u307f\u305f\u3002\u3057\u3070\u3089\u304f\u3057\u305f\u3089\u5897\u6b96\u304c\u3059\u3054\u304f\u9045\u3044\u3051\u3069\u4f55\u304b\u30b3\u30ed\u30cb\u30fc\u304c\u51fa\u3066\u304d\u305f\uff01\u3067\u3001\u8abf\u3079\u3066\u307f\u305f\u3089\u30fb\u30fb\u30fb\u5168\u90e8\u5927\u8178\u83cc\u3060\u3063\u305f\u3002\u5931\u6557\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u6b20\u5931\u306e\u65b9\u6cd5\u3092\u5c11\u3057\u6539\u826f\u3057\u305f\uff08\u03c10 + 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