{"id":3864,"date":"2019-05-17T08:54:26","date_gmt":"2019-05-16T23:54:26","guid":{"rendered":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3864"},"modified":"2020-07-15T09:53:49","modified_gmt":"2020-07-15T00:53:49","slug":"%e7%95%b0%e6%95%b0%e6%80%a7%e7%b4%b0%e8%83%9e%e3%81%af%e4%bd%8e%e6%b5%b8%e9%80%8f%e5%9c%a7%e6%a7%98%e3%81%ae%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e3%82%92%e5%8f%97%e3%81%91%e3%81%a6%e3%81%84%e3%82%8b","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3864","title":{"rendered":"\u7570\u6570\u6027\u7d30\u80de\u306f\u4f4e\u6d78\u900f\u5727\u69d8\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3066\u3044\u308b\uff08\u8ffd\u8a18\u3042\u308a\uff09"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31068692\">Hypo-osmotic-like stress underlies general cellular defects of aneuploidy.<\/a> Tsai HJ, Nelliat AR, Choudhury MI, Kucharavy A, Bradford WD, Cook ME, Kim J, Mair DB, Sun SX, Schatz MC, Li R. Nature. 2019 May 8. doi: 10.1038\/s41586-019-1187-2. PMID:&nbsp;31068692 <\/p>\n\n\n\n<p>\u6700\u8fd1Nature\u8a8c\u306b\u767a\u8868\u3055\u308c\u305f\u8ad6\u6587\u3067\u3059\u3002\u79c1\u306e\u7814\u7a76\u5ba4\u3067\u306f\u904e\u5270\u767a\u73fe\u306b\u3088\u308b\u5897\u6b96\u963b\u5bb3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u3044\u308d\u3093\u306a\u3068\u3053\u308d\u304b\u3089\u3053\u306e\u8ad6\u6587\u306e\u3053\u3068\u304c\u8033\u306b\u5165\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u67d3\u8272\u4f53\u306e\u6570\u3068\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u305f\u3044\u3066\u3044\u306e\u5834\u5408\u305d\u306e\u751f\u7269\u3054\u3068\u306b\u6c7a\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u30d2\u30c8\u306a\u308946\u672c\u3067\u300122\u5bfe\u306e\u5e38\u67d3\u8272\u4f53\u30681\u5bfe\u306e\u6027\u67d3\u8272\u4f53\u304b\u3089\u306a\u308a\u307e\u3059\u3002\u4e00\u500d\u4f53\u306e\u51fa\u82bd\u9175\u6bcd\u306f16\u672c\u306e\u7570\u306a\u308b\u67d3\u8272\u4f53\u3092\u3082\u3063\u3066\u3044\u3066\u3001\u4e8c\u500d\u4f53\u306b\u306a\u308b\u3068\u3053\u308c\u304c16\u672c x2\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7570\u6570\u6027\uff08Aneuploidy\uff09\u3068\u306f\u3001\u3053\u306e\u67d3\u8272\u4f53\u306e\u6570\u304c\u901a\u5e38\u306e\u6570\u3084\u7d44\u307f\u5408\u308f\u305b\u3068\u7570\u306a\u3063\u305f\u72b6\u614b\u306e\u3053\u3068\u3092\u8a00\u3044\u307e\u3059\u3002\u305f\u3044\u3066\u3044\u306e\u5834\u5408\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u7570\u5e38\u3092\u6765\u3057\u307e\u3059\u3002\u304c\u3093\u7d30\u80de\u306f\u975e\u5e38\u306b\u983b\u7e41\u306b\u7570\u6570\u6027\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7570\u6570\u6027\u7d30\u80de\u306e\u3082\u3064\u7279\u6027\u306b\u3064\u3044\u3066\u306f\u3001MIT\u306eAngelika Amon\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u4e00\u9023\u306e\u7814\u7a76\u3067\u975e\u5e38\u306b\u6ca2\u5c71\u306e\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u4e2d\u306e\u5927\u304d\u306a\u767a\u898b\u306e1\u3064\u306f\u3001\u7570\u6570\u6027\u7d30\u80de\u304c\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u306b\u5bfe\u3059\u308b\u5f37\u3044\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\uff08Dephoure, eLIFE 2014\uff09\u3002\u3053\u308c\u306f\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u3082\u308f\u304b\u3063\u305f\u3053\u3068\u3067\u3059\u304c\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306f\u3001\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u9593\u306e\u91cf\u6bd4\u306e\u4e71\u308c\uff08\u5316\u5b66\u91cf\u4e0d\u5747\u8861\uff09\u304c\u751f\u3058\u3066\u3046\u307e\u304f\u8907\u5408\u4f53\u3092\u69cb\u6210\u3067\u304d\u306a\u3044\u6642\u306b\u306f\u3001\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u88c5\u7f6e\u306b\u3088\u3063\u3066\u8fc5\u901f\u306b\u5206\u89e3\u3055\u308c\u307e\u3059\uff08Ishikawa, PLoS Genet 2017\uff09\u3002\u7570\u6570\u6027\u7d30\u80de\u3067\u306f\u3001\u76f8\u624b\u304c\u898b\u3064\u304b\u3089\u306a\u3044\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u304c\u5927\u91cf\u306b\u4f5c\u3089\u308c\u308b\u306e\u3067\u3001\u3053\u308c\u3092\u4e00\u751f\u61f8\u547d\u5206\u89e3\u3057\u3088\u3046\u3068\u3057\u3066\u7d30\u80de\u304c\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n\n\n\n<p>Amon\u3089\u306e\u7570\u6570\u6027\u7d30\u80de\u306e\u7814\u7a76\u3067\u306f\u3001\u4eba\u5de5\u7684\u306b\u4f5c\u308a\u51fa\u3057\u305f\u4e8c\u67d3\u8272\u4f53\u6027\uff08disomy\uff09\u306e\u51fa\u82bd\u9175\u6bcd\u304c\u4e3b\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u500d\u4f53\u9175\u6bcd\u304c\u3082\u306416\u672c\u306e\u67d3\u8272\u4f53\u306e\u305d\u308c\u305e\u308c\u30922\u672c\u306b\u3057\u305fdisomy\u682a\u3092\u69cb\u7bc9\u3057\u3001\u305d\u308c\u3089\u306e\u751f\u7406\u72b6\u614b\u3092\u4f53\u7cfb\u7684\u306b\u8abf\u67fb\u3057\u3066\u7570\u6570\u6027\u306e\u7279\u5fb4\u3092\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u300c\u7570\u6570\u6027\u306e\u4e00\u822c\u7684\u306a\u7279\u5fb4\u3092\u8abf\u3079\u308b\u300d\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3001\u67d3\u8272\u4f53\u6570\u3092\u305d\u308c\u305e\u308c\u5909\u3048\u305f\u9175\u6bcd\u7d30\u80de\u3067\u306f\u306a\u304f\u3001\u67d3\u8272\u4f53\u6570\u304c\u30d0\u30e9\u30d0\u30e9\u306e\u7570\u6570\u6027\u7d30\u80de\u306e\u96c6\u56e3\u3092\u4f5c\u308a\u307e\u3057\u305f\u3002Amon\u3089\u306edisomy\u306e\u3088\u3046\u306b\u500b\u5225\u306b\u4f5c\u6210\u3057\u305f\u7570\u6570\u6027\u7d30\u80de\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3092\u8abf\u3079\u308b\u3068\u3001\u5897\u3048\u305f\u67d3\u8272\u4f53\u304b\u3089\u306e\u8ee2\u5199\u7523\u7269\u304c\u5fdc\u7b54\u3068\u3057\u3066\u898b\u3048\u3066\u3057\u307e\u3044\u3001\u7570\u6570\u6027\u3068\u3044\u3046\u73fe\u8c61\u306e\u4e00\u822c\u7684\u306a\u7279\u5fb4\u304c\u96a0\u308c\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u4eca\u56de\u3001\u7570\u6570\u6027\u7d30\u80de\u306e\u96c6\u56e3\u3092\u4f7f\u3063\u305f\u306e\u3067\u3059\u3002\u3053\u308c\u304c\u3053\u306e\u8ad6\u6587\u306e\u30ad\u30e2\u3068\u8a00\u3048\u307e\u3059\uff08\u9006\u306b\u305d\u308c\u304c\u8a71\u3092\u3084\u3084\u3053\u3057\u304f\u3057\u3066\u3044\u308b\u3068\u3082\u8a00\u3048\u307e\u3059\u304c\uff09\u3002<\/p>\n\n\n\n<p>\u8457\u8005\u3089\u306f\u3001\u7570\u6570\u6027\u7d30\u80de\u96c6\u56e3\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u304b\u3089\u7570\u6570\u6027\u7d30\u80de\u3067\u306e\u307f\u7279\u5fb4\u7684\u306a\u767a\u73fe\u5909\u52d5\u3092\u793a\u3059222\u500b\u306e\u907a\u4f1d\u5b50\u7fa4\uff08common aneuploidy gene-expression : CAGE\uff09\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u7fa4\u3092\u65e2\u5b58\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u3068\u6bd4\u8f03\u3057\u3001\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\uff08hypo-osmotic stress\uff09\u3092\u53d7\u3051\u3066\u3044\u308b\u7d30\u80de\u3068\u8fd1\u3044\u8ee2\u5199\u5fdc\u7b54\u304c\u7570\u6570\u6027\u7d30\u80de\u3067\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4f59\u8ac7\u3067\u3059\u304c\u3001\u3053\u3053\u3067\u4f7f\u308f\u308c\u305f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u306f\u5225\u306e\u30b0\u30eb\u30fc\u30d7\u304c2000\u5e74\u306b\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u89e3\u6790\u3067\u53d6\u5f97\u3057\u305f\u3082\u306e\u3067\u3059\uff08Gasch, Mol. Biol. Cell 2000\uff09\u3002\u305d\u308c\u304c\u3001\u300c\u8ee2\u5199\u5fdc\u7b54\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u300d\u306b\u5229\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u306e\u3082\u3053\u306e\u8ad6\u6587\u306e\u4fa1\u5024\u306e\u3042\u308b\u3068\u3053\u308d\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u306e\u5f8c\u306f\u3001\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u304c\u5b9f\u969b\u306b\u7d30\u80de\u306b\u8d77\u304d\u3066\u3044\u308b\u304b\u3092\u7d30\u80de\u751f\u7269\u5b66\u7684\u306b\u78ba\u8a8d\u3057\u3066\u3044\u304d\u307e\u3059\u3002\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u3068\u306f\u3064\u307e\u308a\u7d30\u80de\u306b\u6c34\u304c\u5165\u308a\u8fbc\u3093\u3067\u30d1\u30f3\u30d1\u30f3\u306b\u81a8\u3089\u3093\u3067\u3044\u308b\u72b6\u614b\u3002\u3060\u304b\u3089\u7d30\u80de\u304c\u786c\u3044\u306f\u305a\u3001\u7d30\u80de\u58c1\u3092\u9175\u7d20\u51e6\u7406\u3067\u5206\u89e3\u3059\u308b\u3068\u7834\u88c2\u3057\u3084\u3059\u3044\u306f\u305a\u3001\u5916\u5411\u304d\u306e\u529b\u304c\u304b\u304b\u3063\u3066\u3044\u308b\u306e\u3067\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u5185\u3078\u306e\u7d30\u80de\u819c\u5c0f\u80de\u306e\u53d6\u308a\u8fbc\u307f\uff09\u304c\u8d77\u3053\u308a\u306b\u304f\u3044\u306f\u305a\u3001\u3068\u3044\u3063\u305f\u3053\u3068\u5b9f\u969b\u306e\u5b9f\u9a13\u3067\u78ba\u304b\u3081\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6b21\u306b\u3001\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u304c\u8d77\u304d\u3066\u3044\u308b\u539f\u56e0\u306b\u3064\u3044\u3066\u8003\u3048\u307e\u3057\u305f\u3002\uff08\u4e0a\u8ff0\u3057\u305f\u3088\u3046\u306b\uff09\u7570\u6570\u6027\u3067\u306f\u3001\u5316\u5b66\u91cf\u4e0d\u5747\u8861\u306b\u3088\u3063\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u304c\u3046\u307e\u304f\u5f62\u6210\u3055\u308c\u306a\u3044\u3002\u3060\u304b\u3089\u4f59\u3063\u305f\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u5b50\u306e\u6570\u304c\u5897\u3048\u3066\u3001\u305d\u308c\u304c\u7d30\u80de\u5185\u306e\u6d78\u900f\u5727\u3092\u4e0a\u3052\u308b\u306e\u3067\u6c34\u304c\u7d30\u80de\u5916\u304b\u3089\u6d78\u5165\u3059\u308b\u3002\u3053\u308c\u304c\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3068\u306a\u3063\u3066\u3044\u308b\u3068\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u3092\u78ba\u304b\u3081\u308b\u305f\u3081\u306b\u8457\u8005\u3089\u304c\u304a\u3053\u306a\u3063\u305f\u306e\u306f\u3001\u6570\u7406\u30e2\u30c7\u30eb\u306b\u3088\u308b\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3068\u7d30\u80de\u306e\u30b5\u30a4\u30ba\u306e\u6bd4\u8f03\u3067\u3001\u4e00\u500d\u4f53\u3068\u4e8c\u500d\u4f53\u306b\u6bd4\u3079\u67d3\u8272\u4f53\u306e\u6bd4\u7387\u304c\u304a\u304b\u3057\u306a\u7570\u6570\u6027\u7d30\u80de\u307b\u3069\u7d30\u80de\u304c\u5927\u304d\u3044\uff08\u81a8\u6f64\u3057\u3066\u3044\u308b\uff09\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u304c\u3093\u7d30\u80de\u3067\u3082\u540c\u3058\u50be\u5411\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u7570\u6570\u6027\u7d30\u80de\u5185\u306f\u7d30\u80de\u5185\u306e\u5bc6\u5ea6\u3082\u9ad8\u3044\u3068\u3002<\/p>\n\n\n\n<p>\u6700\u5f8c\u306b\u7570\u6570\u6027\u7d30\u80de\u7279\u7570\u7684\u306b\u5897\u6b96\u304c\u60aa\u304f\u306a\u308b\u5909\u7570\u4f53\u306e\u53d6\u5f97\u3092\u901a\u3058\u3066\u3001\uff08\u4f4e\u6d78\u900f\u5727\u304c\u751f\u307f\u51fa\u3059\uff09\u30a8\u30f3\u30c9\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u7570\u5e38\u306b\u3088\u308a\u7d30\u80de\u819c\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u3046\u307e\u304f\u3044\u304b\u305a\u3001\u5fc5\u8981\u4ee5\u4e0a\u306b\u30a2\u30df\u30ce\u9178\u3084\u7cd6\u304c\u7d30\u80de\u5185\u306b\u5165\u308a\u8fbc\u3080\u3068\u3044\u3046\u7279\u5fb4\u304c\u7570\u6570\u6027\u7d30\u80de\u306b\u3042\u308b\u3053\u3068\u3092\u8457\u8005\u3089\u306f\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u5f8c\u306b\u3053\u306e\u7814\u7a76\u306b\u5bfe\u3059\u308b\u79c1\u306e\u611f\u60f3\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u7570\u6570\u6027\u7d30\u80de\u3092\u3054\u3061\u3083\u6df7\u305c\u306b\u3057\u3066\u4e00\u822c\u7684\u306a\u6027\u8cea\u3092\u63a2\u3057\u51fa\u3057\u305f\u3053\u3068\u3001\u65e2\u5b58\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u60c5\u5831\u3092\u3046\u307e\u304f\u4f7f\u3063\u3066\u8ee2\u5199\u5fdc\u7b54\u3092\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u3057\u305f\u3053\u3068\u3001\u305d\u3057\u3066\uff08\u8a00\u308f\u308c\u3066\u307f\u308c\u3070\u306a\u308b\u307b\u3069\u3068\u601d\u3046\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5316\u5b66\u91cf\u4e0d\u5747\u8861\u304c\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3092\u751f\u307f\u51fa\u3059\u3068\u3044\u3046\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u63d0\u6848\u306a\u3069\u3001\u3044\u308d\u3044\u308d\u3068\u65ac\u65b0\u306a\u5207\u308a\u53e3\u306e\u3042\u308b\u7814\u7a76\u3060\u3068\u601d\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u304c\u751f\u307f\u51fa\u3055\u308c\u308b\u539f\u56e0\u3001\u7279\u306b\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5316\u5b66\u91cf\u4e0d\u5747\u8861\u304c\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u306e\u539f\u56e0\u306b\u306a\u308b\u300d\u3053\u3068\u304c\u672c\u5f53\u304b\u3069\u3046\u304b\u306f\u3001\u307e\u3060\u7591\u308f\u3057\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u5b50\u6570\u81ea\u4f53\u306f\u6e2c\u3089\u308c\u3066\u3044\u306a\u3044\u3001\u5316\u5b66\u91cf\u4e0d\u5747\u8861\u304c\u8d77\u304d\u308b\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u8fc5\u901f\u306b\u5206\u89e3\u3055\u308c\u308b\uff08\u306f\u305a\uff09\u3001\u7570\u6570\u6027\u7d30\u80de\u3067\u306f\u30a2\u30df\u30ce\u9178\u3084\u7cd6\u306e\u6fc3\u5ea6\u3082\u975e\u5e38\u306b\u9ad8\u3044\uff08\u306e\u3067\u305d\u308c\u304c\u4f4e\u6d78\u900f\u5727\u306e\u539f\u56e0\u3067\u306f\uff1f\uff09\u3001\u307e\u305f\u305d\u3082\u305d\u3082\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u305f\u3089\u9175\u6bcd\u7d30\u80de\u306f\u7d30\u80de\u58c1\u3092\u5f37\u304f\u3057\u3066\u7d30\u80de\u878d\u89e3\u306b\u5bfe\u5fdc\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3063\u305f\u3053\u3068\u306a\u3069\u304c\u305d\u306e\u7406\u7531\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u7570\u6570\u6027\u306b\u3088\u308b\u4f59\u5270\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u304c\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u3067\u3042\u308c\u3070\u3001\u4f59\u5270\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u904e\u5270\u767a\u73fe\u3082\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u306f\u305a\u3067\u3059\u3002\u3053\u306e\u73fe\u8c61\u306f\u305d\u306e\u3088\u3046\u306a\u500b\u5225\u5b9f\u9a13\u3067\u691c\u8a3c\u3067\u304d\u308b\u3082\u306e\u3060\u3068\u601d\u3044\u307e\u3057\u305f\uff08\u305d\u3046\u3044\u3046\u308f\u3051\u3067\u4eca\u79c1\u306e\u7814\u7a76\u5ba4\u3067\u3082\u691c\u8a3c\u5b9f\u9a13\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\uff09\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3044\u3063\u305f\u300c\u8ad6\u4e89\u3092\u5f15\u304d\u8d77\u3053\u3059\u300d\u3053\u3068\u3082\u3001\u3053\u3046\u3044\u3046\u8ad6\u6587\u306e\u4fa1\u5024\u3068\u8a00\u3048\u306a\u304f\u306f\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u901a\u5e38\u306e\u6d41\u308c\u3060\u3068\u3001\u7570\u6570\u6027\u306e\u5927\u5fa1\u6240\u306eAmon\u3089\u30b0\u30eb\u30fc\u30d7\u304c\u3059\u3050\u306b\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306e\u7814\u7a76\u3092\u306f\u3058\u3081\u3001\u9593\u9055\u3063\u3066\u3044\u308b\u3068\u305d\u306e\u3046\u3061\u5426\u5b9a\u8ad6\u6587\u304c\u767a\u8868\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u2014\u2014<\/p>\n\n\n\n<p>2020.7.15 \u8ffd\u8a18<\/p>\n\n\n\n<p>\u4e88\u8a00\u3069\u304a\u308a\uff08\uff1f\uff09\u3001Amon\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u5426\u5b9a\u8ad6\u6587\u304c\u51fa\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32632008\/\">The environmental stress response causes ribosome loss in aneuploid yeast cells.<\/a> Terhorst A, Sandikci A, Keller A, Whittaker CA, Dunham MJ, Amon A.Proc Natl Acad Sci U S A. 2020 Jul 6:202005648. doi: 10.1073\/pnas.2005648117. Online ahead of print.PMID:&nbsp;32632008<\/p>\n\n\n\n<p>\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u3057\u3066\u7528\u3044\u305fEuploid\u306e\u5897\u6b96\u901f\u5ea6\u306f\u65e9\u3044\u305f\u3081\u3001Euploid\u306f\u89e3\u6790\u6642\u306b\u5b9a\u5e38\u671f\u306b\u5165\u3063\u3066\u3057\u307e\u3044\u3001\u9ad8\u6d78\u900f\u5727\u5fdc\u7b54\u3092\u542b\u3080\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u8d77\u3053\u3057\u3066\u3044\u305f\u3002\u5897\u6b96\u306e\u9045\u3044Aneuploid\u306f\u3001\u89e3\u6790\u6642\u306b\u306f\u307e\u3060\u5bfe\u6570\u5897\u6b96\u671f\u306b\u3044\u308b\u305f\u3081\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u3058\u3066\u304a\u3089\u305a\u3001\u305d\u306e\u305b\u3044\u3067\u9ad8\u6d78\u900f\u5727\u5fdc\u7b54\u306e\u9006\u3001\u3064\u307e\u308a\u4f4e\u6d78\u900f\u5727\u5fdc\u7b54\u3092\u8d77\u3053\u3057\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u305f\u3002Euploid\u306e\u5897\u6b96\u671f\u3092\u5408\u308f\u305b\u305f\u3089\u3001Aneuploid\u306e\u307f\u304c\u4f4e\u6d78\u900f\u5727\u5fdc\u7b54\u3092\u793a\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u521d\u3081\u306eRNA-seq\u306e\u30c7\u30fc\u30bf\u304b\u3089Aneuploid\u306e\u7d30\u80de\u304c\u4f4e\u6d78\u900f\u5727\u30b9\u30c8\u30ec\u30b9\u3092\u53d7\u3051\u3066\u3044\u308b\u3068\u3044\u3046\u4eee\u8aac\u3092\u7acb\u3066\u3001\u305d\u306e\u5f8c\u3001\u305d\u308c\u3092\u7acb\u8a3c\u3059\u308b\u30c7\u30fc\u30bf\u3092\u7a4d\u307f\u4e0a\u3052\u305f\u3053\u306e\u8ad6\u6587\u306f\u5168\u5426\u5b9a\u3002\u521d\u3081\u306e\u524d\u63d0\u3068\u306a\u308b\u4eee\u8aac\u304c\u9593\u9055\u3063\u3066\u3044\u305f\u308f\u3051\u3067\u3001\u305d\u306e\u5f8c\u306e\u300c\u7acb\u8a3c\u30c7\u30fc\u30bf\u300d\u306f\u5168\u90e8\u3001\u90fd\u5408\u306e\u826f\u3044\u89e3\u91c8\u3060\u3063\u305f\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3001\u300c\u89e3\u91c8\u306e\u90fd\u5408\u306e\u826f\u3055\u300d\u306b\u79c1\u3082\u9055\u548c\u611f\u3092\u611f\u3058\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u3084\u3063\u3071\u308a\u305d\u3046\u3060\u3063\u305f\u304b\u3068\u3044\u3046\u611f\u3058\u3067\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>These analyses showed that the CAGE gene-expression signature described by Tsai et al. (<a href=\"https:\/\/www.pnas.org\/content\/early\/2020\/07\/02\/2005648117.long#ref-9\">9<\/a>) is an <strong>artifact <\/strong>caused by normalizing the gene expression of actively dividing aneuploid cells to that of euploid control cells that had grown to stationary phase.&nbsp;<\/p><\/blockquote>\n\n\n\n<p>\u30a2\u30fc\u30c6\u30a3\u30d5\u30a1\u30af\u30c8\u3068\u306f\u3063\u304d\u308a\u66f8\u304b\u308c\u3066\u307e\u3059\u306d\u3002\uff65\uff65\uff65\u6016\u3044\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hypo-osmotic-li&#8230;<\/p>\n","protected":false},"author":3,"featured_media":3493,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[1,8,137,9],"tags":[],"class_list":["post-3864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-updates","category-8","category-137","category-9"],"_links":{"self":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3864"}],"version-history":[{"count":4,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3864\/revisions"}],"predecessor-version":[{"id":4171,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/3864\/revisions\/4171"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/media\/3493"}],"wp:attachment":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3864"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}