{"id":3932,"date":"2020-01-24T20:08:43","date_gmt":"2020-01-24T11:08:43","guid":{"rendered":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3932"},"modified":"2020-01-25T12:06:33","modified_gmt":"2020-01-25T03:06:33","slug":"%e9%87%8e%e7%94%9f%e3%81%ae%e9%85%b5%e6%af%8d%e3%81%8c%e7%95%b0%e6%95%b0%e6%80%a7%e3%81%ab%e5%bc%b7%e3%81%84%e7%90%86%e7%94%b1%ef%bc%88%e3%81%a8%e3%81%84%e3%81%86%e3%82%88%e3%82%8a%e5%ae%9f%e9%a8%93","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3932","title":{"rendered":"\u91ce\u751f\u306e\u9175\u6bcd\u304c\u7570\u6570\u6027\u306b\u5f37\u3044\u7406\u7531\uff08\u3068\u3044\u3046\u3088\u308a\u5b9f\u9a13\u5ba4\u9175\u6bcd\u304c\u7570\u6570\u6027\u306b\u5f31\u3044\u7406\u7531\uff09\u304c\u5224\u660e\u3057\u305f"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31909711\">The genetic basis of aneuploidy tolerance in wild yeast.<\/a> Hose J, Escalante LE, Clowers KJ, Dutcher HA, Robinson D, Bouriakov V, Coon JJ, Shishkova E,&nbsp;Gasch&nbsp;AP. Elife. 2020 Jan 7;9. pii: e52063. doi: 10.7554\/eLife.52063.PMID:&nbsp;31909711<\/p>\n\n\n\n<p>\u67d3\u8272\u4f53\u6570\u304c\u901a\u5e38\u306e\u30bb\u30c3\u30c8\u6570\u3068\u306f\u7570\u306a\u308b\u72b6\u614b\u3092\u7570\u6570\u6027\u3068\u8a00\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u51fa\u82bd\u9175\u6bcd\u306e\u4e00\u500d\u4f53\u306e\u67d3\u8272\u4f53\u30bb\u30c3\u30c8\u306f16\u672c\u3001\u4e8c\u500d\u4f53\u306a\u308916\u672c x2\u30bb\u30c3\u30c8\u3067\u3059\u3002\u7570\u6570\u6027\u306f\u3001\u4e00\u822c\u7684\u306b\u751f\u547d\u306e\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30c0\u30a6\u30f3\u75c7\u5019\u7fa4\u306f\u3001\u901a\u5e38\u306f2\u672c\u306e21\u756a\u67d3\u8272\u4f53\u6570\u304c\u30013\u672c\uff08\u30c8\u30ea\u30bd\u30df\u30fc\uff09\u306b\u306a\u308b\u3053\u3068\u306b\u3088\u308a\u767a\u75c7\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7570\u6570\u6027\u304c\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u3001\u51fa\u82bd\u9175\u6bcd\u306e\u4e00\u500d\u4f53\u306b\u304a\u3044\u3066\u305d\u308c\u305e\u308c\u306e\u67d3\u8272\u4f53\u30922\u672c\uff08\u30c0\u30a4\u30bd\u30df\u30fc\uff09\u306b\u6539\u5909\u3057\u305f\u4e00\u9023\u306e\u682a\u3092\u7528\u3044\u3066\u4f53\u7cfb\u7684\u306b\u8abf\u3079\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001MIT\u306eAngerika Amon\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u4e3b\u4f53\u7684\u306b\u304a\u3053\u306a\u3063\u3066\u304d\u305f\u3082\u306e\u3067\u3059\u3002\u305d\u3053\u3067\u306e\u57fa\u672c\u7684\u306a\u767a\u898b\u306f\u3001\u3069\u306e\u67d3\u8272\u4f53\u304c\u30c0\u30a4\u30bd\u30df\u30fc\u3067\u3042\u308b\u304b\u306f\u95a2\u4fc2\u306a\u304f\u3001\u30c0\u30a4\u30bd\u30df\u30fc\u306f\u4e00\u822c\u7684\u306b\u5897\u6b96\u963b\u5bb3\u3092\u8d77\u3053\u3059\u3053\u3068\u3001\u305d\u306e\u7406\u7531\u306f\u5897\u3048\u305f\u67d3\u8272\u4f53\u304b\u3089\u767a\u73fe\u3059\u308b\u591a\u6570\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5168\u4f53\u3068\u3057\u3066\u7d30\u80de\u5185\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u3067\u3042\u308b\u3053\u3068\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001Amon\u3089\u306f\u30c0\u30a4\u30bd\u30df\u30fc\u306b\u3088\u308b\u5897\u6b96\u963b\u5bb3\u3092\u514b\u670d\u3067\u304d\u308b\u5909\u7570\u3092\u540c\u5b9a\u3059\u308b\u306a\u3069\u3057\u3066\u3001\u764c\u7d30\u80de\u304c\u7570\u6570\u6027\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u65e9\u3044\u5897\u6b96\u3092\u7d9a\u3051\u3089\u308c\u308b\u7406\u7531\u3082\u89e3\u660e\u3057\u3066\u304d\u307e\u3057\u305f\u3002Amon\u3089\u306f\u3053\u306e\u30c0\u30a4\u30bd\u30df\u30fc\u9175\u6bcd\u682a\u3092\u7528\u3044\u3066\u7570\u6570\u6027\u304c\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u975e\u5e38\u306b\u6ca2\u5c71\u306e\u767a\u898b\u3092\u7d9a\u3051\u3066\u304d\u305f\u306e\u3067\u3001\u300c\u7570\u6570\u6027\u3068\u3044\u3048\u3070Angerika Amon\u300d\u306f\u3082\u3046\u5408\u3044\u8a00\u8449\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff08\u79c1\u306e\u4e2d\u3067\u306f\uff09\u3002<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=3864\">\u305d\u306e\u3042\u305f\u308a\u306f\u4ee5\u524d\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u3082\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002<\/a><\/p>\n\n\n\n<p>\u3068\u3053\u308d\u304c\u30012015\u5e74\u306b\u30a6\u30a3\u30b9\u30b3\u30f3\u30b7\u30f3\u5927\u5b66\u30de\u30c7\u30a3\u30bd\u30f3\u6821\u306eAudrey Gasch\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u3001eLife\u8a8c\u306b\u4e0b\u8a18\u306e\u8ad6\u6587\u304c\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25955966\">Dosage compensation can buffer copy-number variation in wild yeast.<\/a> Hose J, Yong CM, Sardi M, Wang Z, Newton MA, Gasch AP. Elife. 2015 May 8;4. doi: 10.7554\/eLife.05462. Erratum in:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27006204\">Elife. 2016;5. pii: e15743. doi: 10.7554\/eLife.15743<\/a>.PMID:&nbsp;25955966&nbsp;<\/p>\n\n\n\n<p>\u30bf\u30a4\u30c8\u30eb\u304b\u3089\u306f\u610f\u5473\u304c\u3064\u304b\u307f\u306b\u304f\u3044\u306e\u3067\u3059\u304c\u3001\u8981\u3059\u308b\u306b\u300c\uff08\u5b9f\u9a13\u5ba4\u9175\u6bcd\u3067\u306f\u306a\u3044\uff09\u91ce\u751f\u306e\u9175\u6bcd\u306f\u3001\u7570\u6570\u6027\u306b\u3057\u3066\u3082\u5143\u6c17\u306b\u5897\u6b96\u3059\u308b\uff08\u7570\u6570\u6027\u8010\u6027\u3092\u3082\u3063\u3066\u3044\u308b\uff09\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3001Amon\u306e\u4e00\u9023\u306e\u4ed5\u4e8b\u3092\u4fe1\u3058\u3066\u3044\u308b\u79c1\u304b\u3089\u3059\u308b\u3068\u306b\u308f\u304b\u306b\u306f\u4fe1\u3058\u304c\u305f\u3044\u3082\u306e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u8ad6\u6587\u306b\u5bfe\u3057\u3066\u3001Amon\u30b0\u30eb\u30fc\u30d7\u306f\u9ed9\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3059\u3050\u306b\u4e0a\u8a18\u306e\u8ad6\u6587\u306e\u5185\u5bb9\u306f\u7591\u308f\u3057\u3044\u3068\u3044\u3046\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u540c\u3058\u304feLife\u306b\u767a\u8868\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26949255\">No current evidence for widespread dosage compensation in S. cerevisiae.<\/a> Torres EM, Springer M, Amon A. Elife. 2016 Mar 7;5:e10996. doi: 10.7554\/eLife.10996.PMID:&nbsp;26949255&nbsp;<\/p>\n\n\n\n<p>Gasch\u30b0\u30eb\u30fc\u30d7\u3082\u3053\u306e\u8ad6\u6587\u306b\u524d\u5f8c\u3057\u3066\u518d\u53cd\u8ad6\u6587\u3092\u767a\u8868\u3002\u6fc0\u3057\u3044\u8ad6\u4e89\u304c\u5dfb\u304d\u8d77\u3053\u3063\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26949252\">Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution.<\/a> Gasch AP, Hose J, Newton MA, Sardi M, Yong M, Wang Z. Elife. 2016 Mar 7;5:e14409. doi: 10.7554\/eLife.14409.PMID:&nbsp;26949252<\/p>\n\n\n\n<p>Gasch\u3089\u306f\u3053\u306e\u8ad6\u6587\u3068\u540c\u6642\u306b\u3001\u59cb\u3081\u306e\u8ad6\u6587\u306e\u4e3b\u5f35\u3092\u82e5\u5e72\u5f31\u3081\u308b\u3053\u3068\u306b\u306a\u308b\u4fee\u6b63\u3082\u304a\u3053\u306a\u3063\u3066\u3044\u3066\u3001\u3053\u308c\u3089\u3092\uff08\u3056\u3063\u3068\uff09\u898b\u305f\u79c1\u306f\u3001\u300c\u7570\u6570\u6027\u306b\u3088\u308b\u5897\u6b96\u963b\u5bb3\u306e\u4e00\u822c\u6027\u3092\u5426\u5b9a\u3067\u304d\u308b\u307b\u3069\u5f37\u3044\u4e3b\u5f35\u306f\u3067\u304d\u3066\u3044\u306a\u3044\u306a\u300d\u3068\u601d\u3063\u3066\u3044\u305f\u306e\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066Gasch\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u306e\u4eca\u56de\u306e\u8ad6\u6587\u3067\u3059\u3002\u91ce\u751f\u682a\u304c\u7570\u6570\u6027\u306b\u8010\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u3068\u3044\u3046\u304b\u4e00\u90e8\u306e\u5b9f\u9a13\u5ba4\u682a\u306e\u307f\u304c\u7570\u6570\u6027\u306b\u5f31\u3044\u3053\u3068\u3092\u3001\u3061\u3083\u3093\u3068\u305d\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u5909\u7570\u307e\u3067\u660e\u3089\u304b\u306b\u3057\u3066\u3001\u3050\u3046\u306e\u97f3\u3082\u51fa\u306a\u3044\u307b\u3069\u304d\u3063\u3061\u308a\u3068\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u3057\u3066\u305d\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3068\u306f\u30fb\u30fb\u30fb\u3002<strong>\u77e5\u308b\u4eba\u305e\u77e5\u308bSSD1\uff01 \u7d0d\u5f97\u306eSSD1\uff01<\/strong><\/p>\n\n\n\n<p>\u5b9f\u9a13\u5ba4\u3067\u4f7f\u308f\u308c\u3066\u3044\u308b\u9175\u6bcd\u682a\u306b\u306f\u3001\u304a\u305d\u3089\u304f\u305a\u3063\u3068\u7814\u7a76\u5ba4\u3067\u98fc\u3044\u7d9a\u3051\u3089\u308c\u3066\u3044\u308b\u305b\u3044\u3067\u751f\u3058\u305f\u5909\u7570\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304c\u7814\u7a76\u8005\u306e\u9593\u3067\u5b9f\u9a13\u7d50\u679c\u306e\u9055\u3044\u3092\u751f\u3080\u3053\u3068\u304c\u3057\u3070\u3057\u3070\u3042\u308a\u307e\u3057\u305f\u3002\u305d\u3046\u3044\u3046\u30c8\u30e9\u30d6\u30eb\u306b\u5dfb\u304d\u8fbc\u307e\u308c\u305f\uff08\uff1f\uff09\u7814\u7a76\u8005\u306f\u3001\u305d\u308c\u305e\u308c\u306e\u682a\u306b\u306f\u3069\u3093\u306a\u5909\u7570\u304c\u3042\u3063\u3066\u3001\u3069\u3093\u306a\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u305f\u308a\u3082\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3067\u3001\u8a71\u3092\u623b\u3057\u307e\u3059\u304c\u3001Amon\u30b0\u30eb\u30fc\u30d7\u304c\u30c0\u30a4\u30bd\u30df\u30fc\u3092\u4f5c\u308b\u306e\u306b\u4f7f\u3063\u305f\u306e\u306f<a 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