{"id":4212,"date":"2020-11-12T15:38:01","date_gmt":"2020-11-12T06:38:01","guid":{"rendered":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4212"},"modified":"2022-06-05T14:48:46","modified_gmt":"2022-06-05T05:48:46","slug":"wtc846%ef%bc%9a%e3%81%93%e3%82%8c%e3%81%a7%e6%b1%ba%e3%81%be%e3%82%8a%ef%bc%88%ef%bc%9f%ef%bc%81%ef%bc%89%e3%81%aa%e9%85%b5%e6%af%8d%e3%81%ae%e8%bb%a2%e5%86%99%e5%88%b6%e5%be%a1%e3%82%b7%e3%82%b9","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4212","title":{"rendered":"WTC846\uff1a\u3053\u308c\u3067\u6c7a\u307e\u308a\uff08\uff1f\uff01\uff09\u306a\u9175\u6bcd\u306e\u8ee2\u5199\u5236\u5fa1\u30b7\u30b9\u30c6\u30e0"},"content":{"rendered":"\n

bioRxiv\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b\u3001\u975e\u5e38\u306b\u512a\u308c\u305f\u51fa\u82bd\u9175\u6bcd\u306e\u8ee2\u5199\u5236\u5fa1\u30b7\u30b9\u30c6\u30e0\u306e\u8ad6\u6587\u3067\u3059\uff08\u8ffd\u8a18\uff1aeLife\u306b\u51fa\u7248\u3055\u308c\u307e\u3057\u305f<\/a>\uff09\u3002<\/p>\n\n\n\n

A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery <\/a>Asli\u00a0Azizo\u011flu,\u00a0Roger\u00a0Brent,\u00a0Fabian\u00a0Rudolf doi:<\/strong>\u00a0https:\/\/doi.org\/10.1101\/2019.12.12.874461<\/p>\n\n\n\n

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\u8ee2\u5199\u5236\u5fa1\u306f\u3001\u53e4\u304f\u306f\u751f\u7269\u304c\u672c\u6765\u6301\u3063\u3066\u3044\u308b\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u305d\u306e\u307e\u307e\u4f7f\u3063\u305f\u308a\u3001\u305d\u308c\u3092\u6539\u5909\u3057\u305f\u308a\u3001\u305d\u308c\u304c\u5236\u5fa1\u3067\u304d\u308b\u5316\u5b66\u7269\u8cea\u3092\u4f7f\u3063\u305f\u308a\u3001\u3068\u3044\u3046\u65b9\u6cd5\u3067\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u308c\u304c\u8fd1\u5e74\u306b\u306a\u308b\u3068\u3001\u4eba\u5de5\u7684\u306a\u8ee2\u5199\u56e0\u5b50\u3068\u305d\u308c\u306b\u5fdc\u7b54\u3059\u308b\u4eba\u5de5\u7684\u306a\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u4f7f\u3063\u305f\u5236\u5fa1\u3078\u3068\u6539\u826f\u3055\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u306a\u30c4\u30fc\u30eb\u304c\u6700\u3082\u767a\u9054\u3057\u3066\u3044\u308b\u51fa\u82bd\u9175\u6bcd\uff08S. cerevisiae<\/em>\uff09\u3067\u3082\u3001\u3044\u304f\u3064\u3082\u306e\u300c\u512a\u308c\u305f\u300d\u8ee2\u5199\u5236\u5fa1\u7cfb\u304c\u958b\u767a\/\u5229\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u30d6\u30ed\u30b0\u306e\u904e\u53bb\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u3082\u3044\u304f\u3064\u304b\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\uff08\u4f8b\u3048\u3070\u3053\u3061\u3089<\/a>\uff09\u3002<\/p>\n\n\n\n

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  1. ON\/OFF\u304c\u304d\u308c\u3044\u306b\u3067\u304d\u308b\u3053\u3068\uff08\u6f0f\u308c\u304c\u306a\u3044\u3053\u3068\uff09<\/li>
  2. ON\/OFF\u304c\u85ac\u5264\u306a\u3069\u3067\u7c21\u5358\u306b\u64cd\u4f5c\u3067\u304d\u308b\u3053\u3068<\/li>
  3. \u8ee2\u5199\u91cf\u3092\u8abf\u7bc0\u3067\u304d\u308b\u3053\u3068<\/li>
  4. \u8ee2\u5199\u91cf\u306e\u8abf\u7bc0\uff08\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u30ec\u30f3\u30b8\uff09\u304c\u5e83\u3044\u7bc4\u56f2\u3067\u3067\u304d\u308b\u3053\u3068<\/li>
  5. \u6700\u5927\u8ee2\u5199\u91cf\u304c\u9ad8\u3044\u3053\u3068<\/li>
  6. \u7cfb\u3092\u7d44\u307f\u8fbc\u3080\u306e\u304c\u7c21\u5358\u3067\u3042\u308b\u3053\u3068<\/li>
  7. \u6a19\u7684\u907a\u4f1d\u5b50\u4ee5\u5916\u3078\u306e\u5f71\u97ff\u304c\u5c11\u306a\u3044\u3053\u3068<\/li>
  8. \u7d30\u80de\u9593\u3067\u306e\u3070\u3089\u3064\u304d\u304c\u5c11\u306a\u3044\u3053\u3068<\/li><\/ol>\n\n\n\n

    \u4eca\u56de\u958b\u767a\u3055\u308c\u305f\u8ee2\u5199\u8a98\u5c0e\u7cfb\uff08WTC846<\/sub>\uff09\u306f\u3053\u308c\u3089\u3092\u307b\u307c\u3059\u3079\u3066\u6e80\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u3053\u308c\u307e\u3067\u306b\u5b9f\u73fe\u3067\u304d\u3066\u3044\u306a\u304b\u3063\u305f1\u30014\u30015\u3092\u6e80\u305f\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u304c\u3059\u3054\u3044\u3002\u3057\u304b\u3082\u3001\u305d\u306e\u5b8c\u6210\u306b\u81f3\u308b\u9053\u7b4b\u304c\u8ad6\u7406\u7684\u3067\u3068\u3066\u3082\u7f8e\u3057\u3044\u3002<\/p>\n\n\n\n

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    \u3053\u306e\u7cfb\u306e\u7d44\u307f\u8fbc\u307f\u306f\u6bd4\u8f03\u7684\u7c21\u5358\u3067\u3059\uff086\u3092\u6e80\u305f\u3059\uff09\u3002\u30ea\u30d7\u30ec\u30c3\u30b5\u30fc\u306e\u30b3\u30f3\u30b9\u30c8\u30e9\u30af\u30c8\u3092\u30b2\u30ce\u30e0\u4e0a\u306b\u7d44\u307f\u8fbc\u307f\u3001\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092P7tet.1\u306b\u6539\u5909\u3059\u308b\u3002\u307e\u305f\u3001\u5916\u6765\u306e\u8ee2\u5199\u6291\u5236\u306a\u306e\u30677\u3082\u5b9f\u73fe\u3067\u304d\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u3002\u8ad6\u6587\u3067\u306f\u30018\u3082\u6e80\u305f\u3057\u3066\u3044\u308b\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

    \u3068\u3044\u3046\u308f\u3051\u3067\u3001OFF\u306e\u6642\u306f\u8ee2\u5199\u30bc\u30ed\u3001\u30c6\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u6fc3\u5ea6\u306b\u5fdc\u3058\u3066\u8ee2\u5199\u91cf\u304c\u8abf\u6574\u3067\u304d\u3066\u3001\u6700\u5927TDH3<\/em>\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u4e26\u307f\u306b\u8ee2\u5199\u3067\u304d\u308b\u3001\u5b8c\u74a7\u306a\u7cfb\u304c\u3067\u304d\u3042\u304c\u308a\u307e\u3057\u305f\u3002\u540d\u4ed8\u3051\u3066\u3001Well Tempered Controller846<\/sub> (WTC846<\/sub>) \u3002\u4eca\u5f8c\u306f\u3053\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u9175\u6bcd\u696d\u754c\u3092\u5e2d\u5dfb\u3057\u3066\u3044\u304f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    bioRxiv\u306b\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b…<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[25,22,137,9],"tags":[],"class_list":["post-4212","post","type-post","status-publish","format-standard","hentry","category-25","category-22","category-137","category-9"],"_links":{"self":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4212"}],"version-history":[{"count":8,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4212\/revisions"}],"predecessor-version":[{"id":4314,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4212\/revisions\/4314"}],"wp:attachment":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}