{"id":4272,"date":"2022-04-06T10:06:45","date_gmt":"2022-04-06T01:06:45","guid":{"rendered":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4272"},"modified":"2022-04-07T17:59:34","modified_gmt":"2022-04-07T08:59:34","slug":"alfafold2%e3%81%af%e3%80%8c3d%e3%83%97%e3%83%aa%e3%83%b3%e3%82%bf%e3%83%bc%e3%81%a7%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e6%89%93%e3%81%a1%e5%87%ba%e3%81%97%e3%81%a6%e3%81%bf%e3%82%88","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4272","title":{"rendered":"AlphaFold2\u306f\u300c3D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6253\u3061\u51fa\u3057\u3066\u307f\u3088\u3046\u696d\u754c\u300d\u306b\u3082\u5909\u9769\u3092\u3082\u305f\u3089\u3057\u305f"},"content":{"rendered":"\n

\u5f85\u3061\u671b\u307e\u308c\u305f\u69cb\u9020\u4e88\u6e2c\u306e\u30c4\u30fc\u30eb AlphaFold2 (AF2)<\/h2>\n\n\n\n

\u6700\u8fd1\u306e\u751f\u547d\u79d1\u5b66\u306b\u304a\u3044\u3066\u6700\u3082\u5927\u304d\u306a\u30c8\u30d4\u30c3\u30af\u306f\u3001AI\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u4e88\u6e2c\u306e\u5b9f\u73fe\u3001\u3059\u306a\u308f\u3061AlphaFold2\uff08AF2\uff09\u306e\u767b\u5834\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u4f55\u5341\u5e74\u3082\u5f85\u3061\u671b\u307e\u308c\u305f\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc<\/a>\u3068\u3044\u3063\u3066\u3044\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

AF2\u3092\u4f7f\u3046\u3068\u3001\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u304c\u305d\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u304b\u3089\u9ad8\u7cbe\u5ea6\u3067\u4e88\u6e2c\u3067\u304d\u307e\u3059\u3002\u305d\u3057\u3066\u305d\u306e\u4e88\u6e2c\uff08\u8a08\u7b97\uff09\u306f\u30a2\u30df\u30ce\u9178\u914d\u5217\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3064\u3044\u3066\u306f\u3082\u3046\u7d42\u4e86\u3057\u3066\u3044\u3066\u3001\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3068\u3057\u3066\u516c\u958b\u3055\u308c\u3066\u3044\u307e\u3059<\/a>\u3002\u6211\u304c\uff08\uff1f\uff09\u51fa\u82bd\u9175\u6bcd\uff08Saccharomyces cerevisiae<\/em>\uff09\u306e\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3082\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08SGD\uff09<\/a>\u304b\u3089\u306e\u30ea\u30f3\u30af\u3067\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

AF2\u306e\u4f55\u304c\u3059\u3054\u3044\u304b\u306f\u3044\u308d\u3044\u308d\u306a\u3068\u3053\u308d\u3067\u7d39\u4ecb\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3053\u3053\u3067\u306f\u5272\u611b\u3057\u307e\u3059\u304c\uff08\u4f8b\u3048\u3070\u3053\u3053<\/a>\uff09\u3001\u79c1\u306b\u3068\u3063\u3066\u306f\u300c\u9175\u6bcd\u306e\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6642\u4ee3\u304c\uff08\u79c1\u304c\u751f\u304d\u3066\u3044\u308b\u3046\u3061\u306b\uff09\u6765\u308b\u306a\u3093\u3066\uff01\uff01\u300d\u3068\u3044\u3046\u559c\u3073\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u3053\u308c\u307e\u3067\u306e\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u306f\u30af\u30e9\u30a4\u30aaEM\u3060\u3063\u305f<\/h2>\n\n\n\n

\u3055\u3066\u3001\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7acb\u4f53\u69cb\u9020\u300d\u3068\u3044\u3048\u3070\u3001\u3082\u3061\u308d\u30933D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u306e\u9020\u5f62\u3067\u3059\u3002\u3053\u306e\u30d6\u30ed\u30b0\u3067\u3082\u4f55\u5ea6\u3082\u30bf\u30f3\u30d1\u30af\u8cea\u306e3D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u306e\u6253\u3061\u51fa\u3057<\/a>\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u300c3D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6253\u3061\u51fa\u3057\u3066\u307f\u3088\u3046\u696d\u754c\u300d\uff08\u305d\u3093\u306a\u3082\u306e\u304c\u5b58\u5728\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u77e5\u308a\u307e\u305b\u3093\u304c\u3001\u591a\u5206\u79c1\u3057\u304b\u3044\u307e\u305b\u3093\u304c\uff09\u306b\u3001\u3053\u3053\u6570\u5e74\u3067\u6700\u3082\u5927\u304d\u306a\u30a4\u30f3\u30d1\u30af\u30c8\u3092\u4e0e\u3048\u305f\u6280\u8853\u306f\u306a\u3093\u3068\u3044\u3063\u3066\u3082\u30af\u30e9\u30a4\u30aaEM\u3067\u3057\u3087\u3046\u3002\u3053\u308c\u307e\u3067\u90e8\u5206\u7684\u306b\u3057\u304b\u5206\u304b\u3089\u306a\u304b\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u8907\u5408\u4f53\u306e\u5de8\u5927\u69cb\u9020\u3092\u6b21\u3005\u3068\u660e\u3089\u304b\u306b\u3057\u3001\u305d\u308c\u30923D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u6253\u3061\u51fa\u3059\u305f\u3081\u306e\u30c7\u30fc\u30bf\u3068\u3057\u3066\u63d0\u4f9b\u3057\u7d9a\u3051\u3066\u3044\u308b\u306e\u3067\u3059\u304b\u3089\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u3067\u3001\u30af\u30e9\u30a4\u30aaEM\u306f\u696d\u754c\u6ce3\u304b\u305b\u3067\u3059\u3002\u30e2\u30c7\u30eb\u304c\u5927\u62b5\u5927\u304d\u304f\u3066\u8907\u96d1\u3002\u9020\u5f62\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u3057\u5931\u6557\u3082\u3057\u3084\u3059\u3044\u3001\u8272\u3092\u3064\u3051\u306a\u3044\u3068\u4f55\u304c\u4f55\u3060\u304b\u5206\u304b\u3089\u306a\u3044\u3002\u305d\u3046\u3044\u3046\u610f\u5473\u3067\u3001\u300c\u30af\u30e9\u30a4\u30aaEM\u30e2\u30c7\u30eb\u300d\u306f\u696d\u754c\u4eba\u306b\u3068\u3063\u3066\u6311\u6226\u3057\u304c\u3044\u306e\u3042\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u306a\u306e\u306f\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093<\/a>\u3002<\/p>\n\n\n\n

AF2\u306e\u5909\u9769\u306f\u5929\u7136\u5909\u6027\u9818\u57df (IDR) \u3092\u898b\u305b\u3066\u304f\u308c\u308b\u3068\u3053\u308d\u306b\u3042\u308b<\/h2>\n\n\n\n

AF2\u306b\u8a71\u3092\u3082\u3069\u3057\u307e\u3057\u3087\u3046\u3002AF2\u306f\u696d\u754c\u306b\u3068\u3063\u3066\u306f\u65b0\u305f\u306a\u885d\u6483\u3068\u8a00\u3048\u307e\u3059\u3002\u306a\u3093\u305b\u3001\u3042\u308a\u3068\u3042\u3089\u3086\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6253\u3061\u51fa\u3055\u308c\u308b\u306e\u3092\u5f85\u3063\u3066\u3044\u308b\u72b6\u614b\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u304b\u3089\u3002\u73fe\u5728\u306e\u3068\u3053\u308dAF2\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u69cb\u9020\u306f\uff11\u5206\u5b50\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u308b\u69cb\u9020\u306b\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30af\u30e9\u30a4\u30aaEM\u3067\u660e\u3089\u304b\u306b\u306a\u308b\u3088\u3046\u306a\u8907\u5408\u4f53\u306e\u69cb\u9020\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u3059\u304b\u3089\u3001\u305d\u308c\u307b\u3069\u5927\u304d\u306a\u30e2\u30c7\u30eb\u306f\u306a\u304f\u3001\u6253\u3061\u51fa\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u6050\u3089\u304f\u305d\u306e\u3046\u3061\u8907\u5408\u4f53\u3082\u767b\u9332\u3055\u308c\u3066\u304f\u308b\u3068\u306f\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3055\u3066\u3001\u672c\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u7d39\u4ecb\u3057\u305f\u3044\u300cAF2\u304c\u3082\u305f\u3089\u3057\u305f\u5909\u9769\u300d\u306f\u3001\u5b9f\u306f\u300c\u3044\u308d\u3044\u308d\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u9006\uff08\uff1f\uff09\u306b\u3001\u69cb\u9020\u3092\u4f5c\u3089\u306a\u3044\u90e8\u5206\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u305f<\/strong>\u3068\u3053\u308d\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u4f55\u3089\u304b\u306e\u69cb\u9020\u3092\u3068\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u306e\u304c\u5272\u3068\u4e00\u822c\u7684\u306a\u7406\u89e3\u3067\u3059\u3002\u3068\u3053\u308d\u304c\u8fd1\u5e74\u3001\u6298\u308a\u305f\u305f\u307e\u308c\u3066\u3044\u306a\u3044\u3075\u3089\u3075\u3089\u3057\u305f\u90e8\u5206\u304c\u7d50\u69cb\u305f\u304f\u3055\u3093\u3042\u308a\u3001\u305d\u3053\u304c\u5927\u4e8b\u306a\u4ed5\u4e8b\u3092\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u8a8d\u8b58\u304c\u5e83\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3075\u3089\u3075\u3089\u3057\u305f\u90e8\u5206\u306f\u3001\u5929\u7136\u5909\u6027\u9818\u57df\uff08Intrinsically Disordered Region\uff1aIDR\uff09<\/strong>\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002IDR\u306f\u5b89\u5b9a\u3057\u305f\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u306e\u3067\u3001X\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3084\u30af\u30e9\u30a4\u30aaEM\u306a\u3069\u306e\u69cb\u9020\u89e3\u6790\u6cd5\u3067\u306f\u898b\u308b\u3053\u3068\u306e\u3067\u304d\u306a\u3044\u69cb\u9020\u3067\u3059\uff08NMR\u3060\u3068\u3075\u3089\u3075\u3089\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u5206\u304b\u308b\uff09\u3002\u30a2\u30df\u30ce\u9178\u914d\u5217\u304b\u3089\u306f\u4e88\u6e2c\u3067\u304d\u308b<\/a>\u306e\u3067\u3001\u300c\u3053\u306e\u3042\u305f\u308a\u306fIDR\u3060\u300d\u3068\u3044\u3046\u3053\u3068\u306f\u3067\u304d\u308b\u306e\u3067\u3059\u304c\u30013D\u30e2\u30c7\u30eb\u3067\u898b\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3067\u3057\u305f\u3002<\/p>\n\n\n\n

\u305d\u308c\u3092AF2\u306f\u3084\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3068\u3044\u3046\u304b\u3001\uff08\u304a\u305d\u3089\u304f\uff09\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u3053\u306e\u3042\u305f\u308a\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u4eba\u985e\u304c\u77e5\u3063\u3066\u3044\u308b\u69cb\u9020\u3092\u4f5c\u3089\u306a\u3044\u300d\u3068\u3044\u3046\u4e88\u6e2c\u306b\u3088\u308a\u3001\u305d\u3053\u306b\u69cb\u9020\u3092\u4f5c\u3089\u306a\u3044\u90e8\u5206\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u305b\u3066\u304f\u308c\u308b<\/strong>\u306e\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u4e0b\u306f\u79c1\u305f\u3061\u304c\u7814\u7a76\u306b\u4f7f\u3063\u3066\u3044\u308bNsr1\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306eAF2\u306b\u3088\u308b\u69cb\u9020\u4e88\u6e2c<\/a>\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/a>
\u9175\u6bcd Nsr1\u30bf\u30f3\u30d1\u30af\u8cea\u306eAF2\u306b\u3088\u308b\u69cb\u9020\u4e88\u6e2c\u3002\u5206\u5b50\u306e\u307b\u3068\u3093\u3069\u304c\u300c\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u9818\u57df\uff08IDR\uff09\u300d\u304b\u3089\u3067\u304d\u3066\u3044\u308b\u3053\u3068\u304c\u8996\u899a\u5316\u3055\u308c\u3001\u624b\u306b\u53d6\u308b\u3088\u3046\u306b\u5206\u304b\u308b\u3002\u3002<\/figcaption><\/figure>\n\n\n\n

\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u90e8\u5206\u304c\u591a\u3044\u3068\u601d\u308f\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u306e\u30673D\u69cb\u9020\u306e\u30c7\u30fc\u30bf\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u308c\u3092\u3001\u300c\u3053\u3046\u3044\u3046\u98a8\u306b\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u306a\u3044\u3093\u3060\uff01\u300d\u3068AF2\u306f\u898b\u305b\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u5b9f\u969b\u306b\u306f\u3001\u7d30\u80de\u306e\u4e2d\u3067\u306f\u4ed6\u306e\u5206\u5b50\u3068\u7d50\u5408\u3057\u3066\u3044\u305f\u308a\u3059\u308b\u306e\u3067\u3001Nsr1\u306f\u3053\u3093\u306a\u611f\u3058\u3067\u306f\u5b58\u5728\u3057\u3066\u3044\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u305d\u308c\u3067\u3082\u69cb\u9020\u306e\u611f\u899a\u3092\u3064\u304b\u3080\u306b\u306f\u5341\u5206\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u300c\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u9818\u57df (IDR) \u304c\u5927\u4e8b\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u306e\u306f\u8fd1\u5e74\u306e\u751f\u7269\u5b66\u306e\u30d1\u30e9\u30c0\u30a4\u30e0\u30b7\u30d5\u30c8\u306e\uff11\u3064\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u3001\u69cb\u9020\u3092\u3068\u308b\u9818\u57df\u3057\u304b\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u305b\u3044\u3067\u300c\u69cb\u9020\u3092\u3068\u308b\u9818\u57df\u3057\u304b\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f\u306a\u3044\u300d\u3068\u601d\u3044\u8fbc\u3093\u3067\u3044\u305f<\/strong>\u3053\u3068\u304b\u3089\u306e\u30b7\u30d5\u30c8\u3067\u3059\u3002\u751f\u7269\u60c5\u5831\u5b66\u306e\u4e16\u754c\u3067\u306fIDR\u304c\u5927\u91cf\u306b\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3044\u3061\u65e9\u304f\u8a8d\u8b58\u3055\u308c\u305d\u306e\u6a5f\u80fd\u89e3\u6790\u304c\u9032\u307f\u307e\u3057\u305f\u304c\u3001\u3084\u306f\u308a\u300c\u69cb\u9020\u304c\u898b\u3048\u306a\u3044\u300d\u3053\u3068\u306b\u306f\u5909\u308f\u308a\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002AF2\u306f\u305d\u306eIDR\u3092\u306f\u3063\u304d\u308a\u30fb\u304f\u3063\u304d\u308a\u8996\u899a\u5316\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u305d\u3057\u3066\u3001\u3053\u3053\u304b\u3089\u304c\u3053\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u306e\u795e\u9ac4\u3002\u3053\u306eIDR\u306f3D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u6253\u3061\u51fa\u305b\u308b\u306e\u3067\u3059\uff01<\/strong>\u79c1\u306f\u306f\u3058\u3081\u3001\u300c\u69cb\u9020\u3092\u3068\u3089\u306a\u3044IDR\u306f\u91dd\u91d1\u307f\u305f\u3044\u306b\u7d30\u304f\u30663D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u306f\u3046\u307e\u304f\u6253\u3061\u51fa\u305b\u306a\u3044\u300d\u3068\u601d\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3001\u5b9f\u969b\u306b\u3084\u3063\u3066\u307f\u308b\u3068\u305d\u308c\u306a\u308a\u306b\u539a\u307f\u304c\u3042\u308a\u5341\u5206\u306b\u6253\u3061\u51fa\u3057\u53ef\u80fd\u3067\u3057\u305f\u3002\u4e0a\u306eNsr1\u3092\u6253\u3061\u51fa\u3057\u305f\u3082\u306e\u304c\u4e0b\u306e\u5199\u771f\u3067\u3059\u3002\u624b\u306b\u53d6\u308b\u3088\u3046\u306b\u308f\u304b\u308b\u3060\u3051\u3058\u3083\u306a\u304f\u3066\u3001\u624b\u306b\u53d6\u308c\u308b\uff01\uff01<\/strong><\/p>\n\n\n\n

\"\"<\/a>
Nsr1\u30923D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u6253\u3061\u51fa\u3057\u8272\u3065\u3051\u3057\u305f\u3082\u306e\u3002\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u90e8\u5206\u306f\u7d2b\u8272\u3067\u793a\u3057\u305f\u3002<\/figcaption><\/figure>\n\n\n\n

\u3053\u3046\u3084\u3063\u3066\u6253\u3061\u51fa\u3057\u3066\u307f\u308b\u3068\u3001\u307b\u3093\u3068\u307b\u3068\u3093\u3069\u304c\u30b0\u30cb\u30e3\u30b0\u30cb\u30e3\u3057\u305f\u3001\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u9818\u57df\u3060\u3068\u5206\u304b\u308a\u307e\u3059\u3002IDR\u306e\u3042\u308b\u90e8\u5206\u306b\u306f\u7a81\u8d77\uff08\u30a2\u30eb\u30ae\u30cb\u30f3\u30fc\u30aa\u30ec\u30f3\u30b8\u8272\u3092\u3064\u3051\u305f\uff09\u304c\u5b9a\u671f\u7684\u306b\u7a81\u304d\u51fa\u3057\u3066\u3044\u307e\u3059\u3002Nsr1\u306f\u3053\u306e\u300c\u89e6\u624b\u300d\u3092\u4f7f\u3063\u3066\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u5206\u5b50\u3092\u6349\u3048\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u3002\u305d\u3057\u3066\u305d\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u8a71\u984c\u306e\u6db2-\u6db2\u76f8\u5206\u96e2\u3092\u8d77\u3053\u3059\u306e\u3067\u3059\u3002<\/p>\n\n\n\n

\uff08\u6253\u3061\u51fa\u3057\u3066\u307f\u308b\u3068\uff09IDR\u306b\u306f\u305d\u308c\u306a\u308a\u306e\u5b58\u5728\u611f\u304c\u3042\u308b<\/h2>\n\n\n\n

\u6700\u5f8c\u306b\u79c1\u305f\u3061\u306e\u7814\u7a76\u3068\u95a2\u4fc2\u304c\u3042\u308b\u3001\u3082\u3046\u3072\u3068\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u4eca\u306f\u540d\u524d\u306f\u4f0f\u305b\u3066\u304a\u304d\u307e\u3059\u30fc\u898b\u308b\u4eba\u304c\u898b\u308c\u3070\u3059\u3050\u306b\u5206\u304b\u308b\u3068\u601d\u3044\u307e\u3059\uff09\u3001\u69cb\u9020\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08PDB\uff09\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\uff08\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306a\u306e\u3067\uff09\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u90e8\u5206\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u30023D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u6253\u3061\u51fa\u3057\u3066\uff08\u8272\u3092\u3064\u3051\u3066\uff09\u307f\u308b\u3068\u3053\u3093\u306a\u611f\u3058\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/a>
PDB\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30e2\u30c7\u30eb\u3002\u5b9f\u9a13\u3067\u6c7a\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u300c\u69cb\u9020\u3092\u3068\u308b\u90e8\u5206\u300d\u3057\u304b\u5b58\u5728\u3057\u306a\u3044\u3002<\/figcaption><\/figure>\n\n\n\n

\u4e00\u65b9\u3001AF2\u3067\u69cb\u9020\u4e88\u6e2c\u3057\u305f\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u6253\u3061\u51fa\u3059\u3068\u3001\u898b\u3048\u3066\u3044\u306a\u304b\u3063\u305fIDR\u304c\u898b\u3048\u3066\u304d\u307e\u3059\u3002\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306eIDR\u306f\u3001\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u9577\u3055\u3068\u3057\u3066\u306f\u77ed\u3044\u3051\u308c\u3069\u7acb\u4f53\u69cb\u9020\u3092\u3068\u3089\u306a\u3044\u306e\u3067\u305d\u308c\u306a\u308a\u306b\u5b58\u5728\u611f\u304c\u3042\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u300c\u3053\u306e\u90e8\u4f4d\u3001\u306a\u3093\u304b\u5927\u4e8b\u306a\u4ed5\u4e8b\u3057\u3066\u3093\u3058\u3083\u306a\u3044\u306e\uff1f\u300d\u3068\u601d\u3048\u3066\u304f\u308b\u308f\u3051\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/a>
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\u7d42\u308f\u308a\u306b<\/h2>\n\n\n\n

\u4ee5\u4e0a\u3001AF2\u304c\u300c3D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6253\u3061\u51fa\u3057\u3066\u307f\u3088\u3046\u696d\u754c\u300d\u306b\u3082\u305f\u3089\u3057\u305f\u5909\u9769\u3092\u7d39\u4ecb\u3057\u307e\u3057\u305f\u30023D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6253\u3061\u51fa\u3057\u59cb\u3081\u3066\uff17\u5e74\u307b\u3069\u305f\u3061\u307e\u3059\u3002\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u89e3\u6790\u306e\u65e5\u9032\u6708\u6b69\u304c\u3001\u307e\u3055\u306b\u624b\u306b\u53d6\u308b\u3088\u3046\u306b\u611f\u3058\u3089\u308c\u307e\u3059\u3002\u79c1\u3082\u3053\u306e\u9032\u6b69\u306b\u8ca0\u3051\u306a\u3044\u3088\u3046\u306b\uff083D\u30d7\u30ea\u30f3\u30bf\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6253\u3061\u51fa\u3059\uff09\u6280\u8853\u3092\u78e8\u3044\u3066\u3044\u3053\u3046\u3068\u601d\u3044\u307e\u3059\u3002\u6b21\u306b\u6765\u308b\u306e\u306f\u4eba\u5de5\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u306a\u3002<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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