{"id":4474,"date":"2024-10-20T14:14:15","date_gmt":"2024-10-20T05:14:15","guid":{"rendered":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4474"},"modified":"2024-10-21T10:27:13","modified_gmt":"2024-10-21T01:27:13","slug":"%e5%87%ba%e8%8a%bd%e9%85%b5%e6%af%8d%e3%81%ae%e6%9c%80%e5%bc%b7%e3%83%97%e3%83%ad%e3%83%a2%e3%83%bc%e3%82%bf%e3%83%bc%e3%82%92%e4%bd%9c%e3%82%8b","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4474","title":{"rendered":"\u51fa\u82bd\u9175\u6bcd\u306e\u6700\u5f37\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u4f5c\u308b"},"content":{"rendered":"\n<p><a href=\"https:\/\/doi.org\/10.1093\/femsyr\/foae032\">Improving the Z<sub>3<\/sub>EV promoter system to create the strongest yeast promoter<\/a>&nbsp; <\/p>\n\n\n\n<p>Rina Higuchi,&nbsp;Yuri Fujita,&nbsp;Shotaro Namba,&nbsp;Hisao Moriya <em>FEMS Yeast Research<\/em>, foae032,&nbsp;<\/p>\n\n\n\n<p>\u6700\u8fd1\u767a\u8868\u3057\u305f\u79c1\u305f\u3061\u306e\u8ad6\u6587\u306e\u7d39\u4ecb\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u51fa\u82bd\u9175\u6bcd\uff08<em>Saccharomyces cerevisiae<\/em>\uff09\u3067\u65e2\u5b58\u306e\u6700\u5f37<em>TDH3<\/em>\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e1.4\u500d\u306e\u5f37\u5ea6\u3092\u6301\u3064\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u306f\u3001\u6700\u5f37\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u4f5c\u308d\u3046\u3068\u3057\u305f\u30e2\u30c6\u30a3\u30d9\u30fc\u30b7\u30e7\u30f3\u3084\u30011.4\u500d\u306e\u6301\u3064\u610f\u5473\u3001\u4eca\u5f8c\u3053\u306e\u7814\u7a76\u306f\u3069\u3053\u306b\u9032\u3080\u306e\u304b\u3001\u306a\u3069\u8ad6\u6587\u306b\u306f\u66f8\u3044\u3066\u3044\u306a\u3044\u88cf\u8a71\u3092\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u306a\u305c\u6700\u5f37\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u5fc5\u8981\u3060\u3063\u305f\u306e\u304b\uff1f<\/h2>\n\n\n\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u3067\u306f\u3001\u518d\u4e09\u3001\u9175\u6bcd\u7814\u7a76\u3067\u7528\u3044\u3089\u308c\u308b<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?s=%E3%83%97%E3%83%AD%E3%83%A2%E3%83%BC%E3%82%BF%E3%83%BC\">\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u3064\u3044\u3066\u7d39\u4ecb\u3057\u3066\u304d\u307e\u3057\u305f<\/a>\u3002\u79c1\u305f\u3061\u306e\u30e1\u30a4\u30f3\u30c6\u30fc\u30de\u304c\u300c<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?s=%E9%81%8E%E5%89%B0%E7%99%BA%E7%8F%BE\">\u904e\u5270\u767a\u73fe<\/a>\u300d\u3067\u3001\u305d\u306e\u305f\u3081\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u7684\u8981\u7d20\u304c\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3060\u304b\u3089\u3067\u3059\u3002\u305d\u306e\u4e2d\u3067\u3001\u4f55\u5ea6\u304b\u6700\u5f37\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff08\u3068\u305d\u306e\u6539\u5909\uff09\u306b\u3064\u3044\u3066\u3082\u66f8\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u51fa\u82bd\u9175\u6bcd\u306e\u5185\u5728\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u4e2d\u3067\u6700\u5f37\u306e\u3082\u306e\u306f<em>TDH3<\/em>\uff08<em>GPD<\/em>\uff09\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3067\u3059\uff08\u4ee5\u964d\u3001\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092<em>pro<\/em>\u3068\u8868\u8a18\u3057\u307e\u3059\uff09\u30022022\u5e7411\u6708\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3067\u306f\u3001\u3053\u308c\u3092AI\u306e\u4e88\u6e2c\u306b\u3082\u3068\u3065\u3044\u3066\u3055\u3089\u306b\u5f37\u304f\u3057\u3088\u3046\u3068\u3057\u3066<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4325\">\u5931\u6557\u3057\u305f\u3053\u3068\u3092\u66f8\u304d\u307e\u3057\u305f<\/a>\u3002\u307e\u305f\u3001<em>TDH3pro<\/em>\u3092\u85ac\u5264\u3067\u5236\u5fa1\u53ef\u80fd\u306b\u3057\u305f<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4212\">WTC846\u30b7\u30b9\u30c6\u30e0<\/a>\u304c\u4f5c\u3089\u308c\u3066\u3044\u307e\u3059\u3002WTC846\u306e\u7d39\u4ecb\u306e\u969b\u306b\u306f\u3001\u300c\u3053\u308c\u3067\u6c7a\u307e\u308a\uff1f\uff01\u300d\u3068\u66f8\u3044\u305f\u3088\u3046\u306b\u3001WTC846\u30b7\u30b9\u30c6\u30e0\u306f\u5f37\u5ea6\u3082\u5236\u5fa1\u6027\u3082\u6587\u53e5\u306a\u3057\u3001\u73fe\u6642\u70b9\u3067\u3044\u3061\u3070\u3093\u30aa\u30b9\u30b9\u30e1\u306a\u767a\u73fe\u7cfb\u3067\u3001<span style=\"text-decoration: underline;\">\u9175\u6bcd\u3067\u3044\u3044\u611f\u3058\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3055\u305b\u305f\u3051\u308c\u3070WTC846\u3092\u4f7f\u3063\u3068\u3051<\/span>\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3068\u3053\u308d\u304c\u3001<em>TDH3pro<\/em>\u3084WTC846\u306f\u3001<strong>\u79c1\u305f\u3061\u306b\u3068\u3063\u3066\u306f<\/strong>\u307e\u3060\u5f37\u5ea6\u4e0d\u8db3\u3067\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u3069\u3093\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3069\u308c\u3060\u3051\u904e\u5270\u767a\u73fe\u3057\u305f\u3089\u7d30\u80de\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u306e\u304b\u3092\u8abf\u3079\u3066\u304d\u307e\u3057\u305f\u3002\u3044\u308d\u3044\u308d\u8abf\u3079\u3066\u3044\u308b\u3046\u3061\u884c\u304d\u3064\u3044\u305f\u306e\u306f\u3001\u5927\u91cf\u306b\u767a\u73fe\u3055\u305b\u3066\u3082\u7d30\u80de\u306e\u6a5f\u80fd\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u306b\u304f\u3044\u30fc<a href=\"https:\/\/elifesciences.org\/reviewed-preprints\/99572\">\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3057\u305f<\/a>\u3002\u3053\u306e\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3001<em>TDH3pro<\/em>\u3068\u591a\u30b3\u30d4\u30fc\u30d7\u30e9\u30b9\u30df\u30c9\u306e\u7d44\u307f\u5408\u308f\u305b\uff08\u3059\u306a\u308f\u3061\u6700\u5f37\u306e\u767a\u73fe\u7cfb\uff09\u3067\u767a\u73fe\u3055\u305b\u308b\u3068\u3001\u7d30\u80de\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u306e40\uff05\u304f\u3089\u3044\u304c\u3053\u306e\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u9175\u6bcd\u306f\u5897\u6b96\u3092\u7d9a\u3051\u308b\u4e8b\u304c\u3067\u304d\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u9175\u6bcd\u306f\u3082\u3063\u3068\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u53d7\u3051\u5165\u308c\u3089\u308c\u308b\u306e\u3067\u3059\u3002\u305d\u308c\u3067\u306f\u3001\u3053\u306e\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3069\u3093\u3069\u3093\u4e0a\u3052\u3066\u3044\u3063\u305f\u3089\u3001\u9175\u6bcd\u306f\u4f55\uff05\u307e\u3067\u8010\u3048\u3089\u308c\u308b\u306e\u3060\u308d\u3046\u304b\uff1f \u8010\u3048\u3089\u308c\u306a\u304f\u306a\u3063\u305f\u9175\u6bcd\u7d30\u80de\u306f\u3069\u3093\u306a\u72b6\u614b\u306b\u306a\u308b\u306e\u3060\u308d\u3046\u304b\uff1f <\/p>\n\n\n\n<p>\u7d30\u80de\u5185\u304c\uff11\u7a2e\u985e\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u306b\u306a\u308b\u3053\u3068\u306f\u3042\u308a\u5f97\u306a\u3044\u306e\u3067\u3001\u5fc5\u305a\u9650\u754c\u304c\u3042\u308b\u3002\u305d\u306e\u9650\u754c\u306f\u3069\u308c\u304f\u3089\u3044\u306a\u306e\u304b\u3001\u306a\u306b\u304c\u9650\u754c\u3092\u304d\u3081\u3066\u3044\u308b\u306e\u304b\u3001\u9650\u754c\u306b\u9054\u3057\u305f\u3068\u304d\u7d30\u80de\u306f\u3069\u3093\u306a\u4e0d\u5177\u5408\u3092\u8d77\u3053\u3059\u306e\u304b\u3001\u3042\u308b\u3044\u306f\u7d30\u80de\u306f\u9650\u754c\u306b\u6297\u3063\u3066\u4f55\u304b\u5fdc\u7b54\u3059\u308b\u306e\u304b\uff1f \uff65\uff65\uff65\u3053\u308c\u304c\u77e5\u308a\u305f\u3044\u3002<\/p>\n\n\n\n<p>\u305d\u3053\u3067\u554f\u984c\u306b\u306a\u3063\u305f\u306e\u306f\u3001\u767a\u73fe\u7cfb\u306e\u5f37\u5ea6\u4e0d\u8db3\u3067\u3059\u3002\u65e2\u5b58\u306e\u6700\u5f37\u767a\u73fe\u7cfb\u3092\u4f7f\u3063\u3066\u3082\u3001\u9650\u754c\u307e\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3063\u3066\u304f\u308c\u306a\u3044\u3002\uff65\uff65\uff65\u3068\u3044\u3046\u308f\u3051\u3067\u3001\u6700\u5f37\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u63a2\u3059\u65c5\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u898b\u843d\u3068\u3057\u3066\u3044\u305fP3\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc<\/h2>\n\n\n\n<p>\u3061\u306a\u307f\u306b\u300140\uff05\u3082\u4f5c\u308c\u308b\u306e\u306f\u3001\u79c1\u305f\u3061\u304c\u898b\u3064\u3051\u305f\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3060\u3051\u3067\u3059\u3001\u4ed6\u306b\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3067\u3057\u3087\u3046\u3002\u307b\u3068\u3093\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u305a\u30fc\u3063\u3068\u4f4e\u3044\u767a\u73fe\u91cf\u3067\u9175\u6bcd\u306e\u5897\u6b96\u304c\u6b62\u307e\u308a\u307e\u3059\u3002\u306a\u306e\u3067\u3001\u4e0a\u8ff0\u306eWTC846\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u76ee\u7684\u3067\u5341\u5206\u306a\u5f37\u5ea6\u3068\u5236\u5fa1\u6027\u3092\u6301\u3061\u3001\u3082\u3063\u3068\u5f37\u3044\u3082\u306e\u304c\u5fc5\u8981\u3068\u666e\u901a\u601d\u308f\u306a\u3044\u3002\u52a0\u3048\u3066\u3001\u81ea\u8eab\u306e<em>TDH3pro<\/em>\u306e\u6539\u826f\u306b\u3082\u5931\u6557\u3057\u305f\u306e\u3067\u3001\u3082\u3046\u3053\u308c\u304c\u9175\u6bcd\u306e\u9650\u754c\u306a\u3093\u3060\u308d\u3046\u3068\u306a\u3093\u3068\u306a\u304f\u601d\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u305d\u3093\u306a\u4e2d\u3067\u898b\u3064\u3051\u305f\u306e\u304c<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-15977-4\">\u3053\u306e\u8ad6\u6587\uff08Kotopka &amp; Smolke 2020\uff09<\/a><sup>1<\/sup>\u3067\u3001\u4eba\u5de5\u77e5\u80fd\u3092\u4f7f\u3063\u3066\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u6539\u826f\u3059\u308b\u8a66\u307f\u304c\u306a\u3055\u308c\u3066\u304a\u308a\u3001\u6700\u7d42\u7684\u306b<em>TDH3<\/em>\uff08<em>GPD<\/em>\uff09<em>pro<\/em>\u306f1.3\u500d\u307b\u3069\u5897\u5f37\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u3053\u306e\u8ad6\u6587\u4e2d\u3067\u305d\u308c\u3088\u308a\u3082\u76ee\u3092\u5f15\u3044\u305f\u306e\u306f\u3001\u300cP3<em>pro<\/em>\u300d\u3067\u3057\u305f\u3002pZEV\u30b7\u30ea\u30fc\u30ba\uff08\u4e0b\u56f3\uff09\u306f\u3001McIsaac\u3089\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u3066\u304d\u305f\u4eba\u5de5\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3067\u3001\u9175\u6bcd\u306e<em>GAL1pro<\/em>\u3092\u6539\u5909\u3057\u3001\u4eba\u5de5\u8ee2\u5199\u56e0\u5b50Z3EV\u306e\u7d50\u5408\u90e8\u4f4d\u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u3067\u03b2-\u30a8\u30b9\u30c8\u30e9\u30b8\u30aa\u30fc\u30eb\u306b\u3088\u308b\u8a98\u5c0e\u3092\u53ef\u80fd\u306b\u3057\u305f\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3067\u3059\u3002P3<em>pro<\/em>\u306f\u3001pZEV\u30b7\u30ea\u30fc\u30ba\u306e\u4e2d\u3067\u3082\u3082\u3063\u3068\u3082\u767a\u73fe\u5f37\u5ea6\u306e\u9ad8\u3044\u3082\u306e\u30672014\u5e74\u306b<a href=\"https:\/\/academic.oup.com\/nar\/article\/42\/6\/e48\/2438394?login=true\">\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059 (McIsaac 2014\uff09<\/a><sup>2<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/image.png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"234\" src=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/image.png\" alt=\"\" class=\"wp-image-4475\" srcset=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/image.png 600w, https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/image-300x117.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>TDH3<\/em><em>pro<\/em>\uff08<em>pGPD<\/em>\uff09\u3068pZEV\u3002Kotopka &amp; Smolke 2020\u3088\u308a<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\">\u5f15\u7528<\/a>\u3002<\/figcaption><\/figure>\n\n\n\n<p>pZEV\u306f\u3001\u958b\u767a\u5f53\u521d\u304b\u3089\u79c1\u3082\u6ce8\u76ee\u3057\u3066\u3044\u3066\u4f7f\u3063\u3066\u307f\u305f\u3053\u3068\u3082\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u5f37\u5ea6\u306f<em>TDH3pro<\/em>\u306b\u306f\u53ca\u3070\u306a\u3044\u3068\u3057\u3066\u305d\u308c\u4ee5\u4e0a\u4f7f\u3046\u306e\u3092\u3084\u3081\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3001<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-15977-4\">Kotopka &amp; Smolke 2020<\/a>\u3092\u3088\u304f\u8aad\u3093\u3067\u307f\u308b\u3068\u3001\u3069\u3046\u3084\u3089P3<em>pro<\/em>\u306f<em>TDH3pro<\/em>\u3068\u540c\u3058\u304b\u305d\u308c\u4ee5\u4e0a\u306e\u5f37\u5ea6\u3092\u6301\u3064\u3088\u3046\u3067\u3057\u305f\u3002\u300c\u305d\u3093\u306a\u3053\u3068\u3042\u308b\u308f\u3051\u306a\u3044\uff01\u300d\u3068\u60f3\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u79c1\u304c\u4f7f\u3063\u3066\u3044\u305f\u306e\u306fP3<em>pro<\/em>\u306e\uff11\u3064\u524d\u306e\u30d0\u30fc\u30b8\u30e7\u30f3<sup>3<\/sup>\u3067\u3001P3<em>pro<\/em>\u306f\u4f7f\u3063\u305f\u3053\u3068\u304c\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u3002\u305f\u3060\u3057\u3001<a href=\"https:\/\/www.nature.com\/articles\/s41467-020-15977-4\">Kotopka &amp; Smolke 2020<\/a>\u306b\u3088\u308bP3<em>pro<\/em>\u306e\u5f37\u5316\u306f\u5931\u6557\u3057\u3066\u3044\u3066\u3001P3<em>pro<\/em>\u3088\u308a\u308f\u305a\u304b\u306b\u5f37\u3044\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u3067\u304d\u305f\u3060\u3051\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">P3\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u6539\u826f\u3057\u305f\u3089\u6700\u5f37\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u304c\u3067\u304d\u305f<\/h2>\n\n\n\n<p>\u3044\u305a\u308c\u306b\u305b\u3088\u3001P3<em>pro<\/em>\u306f\u305d\u308c\u306a\u308a\u306b\u5f37\u305d\u3046\u306a\u306e\u3067\u3001\u81ea\u5206\u305f\u3061\u3067\u8a66\u3057\u3066\u307f\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306eDNA\u914d\u5217\u3092\u79c1\u304c\u624b\u306b\u5165\u308c\u3066\u5408\u6210\u3057\u3066\u3001\u5b66\u751f\u306eH\u3055\u3093\u306b\u5b9f\u9a13\u3092\u3057\u3066\u3082\u3089\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u6700\u521d\u306e\u7d50\u679c\u306f\u3001\u300c<em>TDH3pro<\/em>\u3088\u308a\u5f37\u304f\u306f\u306a\u3044\u300d\u3068\u3044\u3046\u79c1\u306e\u4e88\u60f3\u901a\u308a\u3067\u3057\u305f\u3002\u300cOK\u3002\u305d\u3093\u306a\u3082\u3093\u3060\u3088\u306a\u3002\u6700\u5f37<em>TDH3pro<\/em>\u306b\u306f\u52dd\u3066\u306a\u3044\u3055\u3002\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u69cb\u9020\u56f3\u3082\u63cf\u3044\u3066\u30e9\u30dc\u30bb\u30df\u30ca\u30fc\u767a\u8868\u3057\u3066\u300d\u3068H\u3055\u3093\u983c\u307f\u307e\u3057\u305f\u3002\u3057\u3070\u3089\u304f\u3057\u3066\u3001H\u3055\u3093\u3001\u300c\u6e21\u3055\u308c\u305fP3<em>pro<\/em>\u306e\u914d\u5217\u3001\u306a\u3093\u304b\u304a\u304b\u3057\u3044\u3067\u3059\u300d\u3068\u3002P3<em>pro<\/em>\u306b\u306f\u3001Z3EV\u306e\u7d50\u5408\u90e8\u4f4d\u304c<strong>6\u30ab\u6240<\/strong>\u3042\u308a\u307e\u3059\u3002\u306a\u305c\u304b\u79c1\u304c\u5408\u6210\u3057\u305fP3<em>pro<\/em>\u306b\u306f<strong>4\u30ab\u6240<\/strong>\u3057\u304b\u306a\u304b\u3063\u305f\u3002\u3044\u307e\u3060\u306b\u3069\u3053\u304b\u3089\u9593\u9055\u3063\u305f\u914d\u5217\u3092\u624b\u306b\u5165\u308c\u305f\u306e\u304b\u5206\u304b\u3089\u3093\u306e\u3067\u3059\u304c\u3001\u3044\u305a\u308c\u306b\u305b\u3088\u30df\u30b9\u3063\u305f\u3002<\/p>\n\n\n\n<p>\u3068\u3044\u3046\u3053\u3068\u3067\u3061\u3083\u3093\u3068\u3057\u305fP3<em>pro<\/em>\uff08\u5f53\u6642\u306ftrueP3\u3068\u547c\u3093\u3067\u3044\u305f\uff09\u3092\u8a66\u3057\u3066\u307f\u305f\u3089\u3001\u306a\u3093\u3068<em>TDH3pro<\/em>\u3088\u308a\u3061\u3087\u3063\u3068\u5f37\u3044\u3002\u540c\u6642\u306b\u3053\u306e\u6642\u601d\u3044\u307e\u3057\u305f\u3002<span style=\"text-decoration: underline;\">4\u30ab\u6240\u3088\u308a6\u30ab\u6240\u306e\u65b9\u304c\u5f37\u3044\u306e\u306a\u3089\u3001\u3082\u3063\u3068\u5897\u3084\u3057\u305f\u3089\u3082\u3063\u3068\u5f37\u304f\u306a\u308b\u3093\u3058\u3083\u306a\u3044\u304b<\/span>\u3002McIsaac 2014\u3067\u306f\u3001Z3EV\u306e\u7d50\u5408\u90e8\u4f4d\u306e\u6570\u3092\u5897\u3084\u3057\u305f\u308a\u914d\u7f6e\u3092\u63db\u3048\u305f\u308a\u3057\u3066\u3001\u3069\u308c\u304c\u826f\u3055\u305d\u3046\u304b\u3092\u8abf\u3079\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u306a\u305c\u304b6\u30ab\u6240\u4ee5\u4e0a\u5897\u3084\u3057\u3088\u308a\u5f37\u304f\u3057\u3088\u3046\u3068\u306f\u3057\u3066\u306a\u304b\u3063\u305f\u3002\u601d\u3063\u305f\u901a\u308a\u3001\u7d50\u5408\u90e8\u4f4d\u3092\u5897\u3084\u3057\u3066\u3044\u304f\u3068\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306f\u3069\u3093\u3069\u3093\u5f37\u304f\u306a\u308a\u307e\u3057\u305f\u3002\u6700\u7d42\u7684\u306b\u591a\u30b3\u30d4\u30fc\u30d7\u30e9\u30b9\u30df\u30c9\u3067\u306f+6\uff08P36<em>pro<\/em>\uff09\u3067\u6700\u5f37\uff08<em>TDH3pro<\/em>\u306e<strong>1.4\u500d<\/strong>\uff09\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/5018551ee02af45d87fb36c0e8e73e2f.png\"><img decoding=\"async\" src=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/wp-content\/uploads\/2024\/10\/5018551ee02af45d87fb36c0e8e73e2f-1024x430.png\" alt=\"\" class=\"wp-image-4485\"\/><\/a><figcaption class=\"wp-element-caption\">Z3EV\u306e\u7d50\u5408\u90e8\u4f4d\u3092\u5897\u3084\u3057\u3066P3\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3092\u6539\u826f\u3002Higuchi 2024\u3088\u308a\u5f15\u7528\u3002<\/figcaption><\/figure>\n\n\n\n<p>\u79c1\u305f\u3061\u306f\u3068\u306b\u304b\u304f\u305f\u304f\u3055\u3093\u767a\u73fe\u3057\u305f\u3044\u3068\u3044\u3046\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u3067\u958b\u767a\u3057\u305f\u306e\u3067\u3001\u591a\u30b3\u30d4\u30fc\u30d7\u30e9\u30b9\u30df\u30c9\u3067\u3053\u3053\u307e\u3067\u5b9f\u9a13\u3057\u305f\u306e\u3067\u3059\u304c\u3001\u672c\u6765\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306e\u6d3b\u6027\u306f\u30b7\u30f3\u30b0\u30eb\u30b3\u30d4\u30fc\u3067\u8a55\u4fa1\u3059\u3079\u304d\u3067\u3059\u3002\u5b9f\u969b\u3001\u30ec\u30d3\u30e5\u30fc\u30a2\u30fc\u306b\u6307\u6458\u3055\u308c\u305f\u306e\u3067\u3001\u30b7\u30f3\u30b0\u30eb\u30b3\u30d4\u30fc\u306e\u5b9f\u9a13\u3082\u884c\u3044\u307e\u3057\u305f\u3002\u3001\u30b7\u30f3\u30b0\u30eb\u30b3\u30d4\u30fc\u30d7\u30e9\u30b9\u30df\u30c9\u3067\u306f+8\uff08P38<em>pro<\/em>\uff09\u3067\u6700\u5f37\u3068\u306a\u308a\u3001<em>TDH3pro<\/em>\u306e<strong>1.8\u500d<\/strong>\u306e\u5f37\u5ea6\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>1.4\u500d\u30841.8\u500d\u3001\u305f\u3044\u3057\u305f\u4e8b\u306f\u306a\u3044\u3088\u3046\u306b\u601d\u3048\u307e\u3059\u3002\u3051\u3069\u3001\u305d\u3082\u305d\u3082\u6700\u5f37\u306e\u3082\u306e\u3092\u3053\u308c\u3060\u3051\u4e0a\u3052\u305f\u306e\u306f\u3059\u3054\u3044\u3053\u3068\u3067\u3059\u3002\u30b9\u30dd\u30fc\u30c4\u306e\u4e16\u754c\u8a18\u9332\u304c1.8\u500d\u306b\u306a\u3063\u305f\u3089\u3068\u3093\u3067\u3082\u306a\u3044\u3067\u3057\u3087\u3046\u3002<a href=\"https:\/\/ja.wikipedia.org\/wiki\/%E3%83%8D%E3%82%A4%E3%82%B5%E3%83%B3%E3%82%BA%E5%9B%BD%E9%9A%9B%E3%83%9B%E3%83%83%E3%83%88%E3%83%89%E3%83%83%E3%82%B0%E6%97%A9%E9%A3%9F%E3%81%84%E9%81%B8%E6%89%8B%E6%A8%A9\">\u5c0f\u6797\u5c0a\u3055\u3093\u306f\u30db\u30c3\u30c8\u30c9\u30c3\u30b0\u306e\u65e9\u98df\u3044\u8a18\u9332\u30922\u500d\u3057\u3066\u30bb\u30f3\u30bb\u30fc\u30b7\u30e7\u30f3\u3092\u5dfb\u304d\u8d77\u3053\u3057\u305f<\/a>\u3089\u3057\u3044\u3067\u3059\u3002\u305d\u308c\u304f\u3089\u3044\u3059\u3054\u3044\u3053\u3068\u306a\u3093\u3067\u3059\u3088\u3002\u6700\u521d\u306b\u6295\u7a3f\u3057\u305f\u96d1\u8a8c\u3067\u306f\u30a8\u30c7\u30a3\u30bf\u30fc\u306b\u30ea\u30b8\u30a7\u30af\u30c8\u3055\u308c\u305f\u306e\u3067\u3059\u304c\u3001\u300c\u3053\u306e\u4fa1\u5024\u304c\u5206\u304b\u3089\u3093\u306e\u304b\u3044\uff01\u300d\u3068\u601d\u3063\u305f\u308f\u3051\u3067\u3059\u3088\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u304c\u3053\u306e\u30a8\u30f3\u30c8\u30ea\u30fc\u3092\u66f8\u3044\u305f\u30e2\u30c1\u30d9\u30fc\u30b7\u30e7\u30f3\u3060\u3063\u305f\u308a\u3082\u3059\u308b\u308f\u3051\u3067\u3059\u3088\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6700\u5f8c\u306b\uff1a\u30df\u30b9\u304b\u3089\u30d2\u30f3\u30c8\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u3082\u3042\u308b\u3068\u3044\u3046\u8a71<\/h2>\n\n\n\n<p>\u3068\u3044\u3046\u308f\u3051\u3067\u3001\u6700\u5f37\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u958b\u767a\u306e\u8a71\u3067\u3057\u305f\u3002\u9762\u767d\u3044\u3068\u601d\u3046\u306e\u306f\u3001\u306f\u3058\u3081\u306b\u79c1\u304c\u30dd\u30ab\u3057\u3066\u5909\u306aP3<em>pro<\/em>\u3092\u4f5c\u3063\u3066\u3057\u307e\u3063\u305f\u7d50\u679c\u3068\u3057\u3066\u3001\u7d50\u5408\u90e8\u4f4d\u3092\u5897\u3084\u305b\u3070\u5f37\u304f\u306a\u308b\u304b\u3082\u3068\u3044\u3046\u601d\u3044\u3064\u304d\u306b\u305f\u3069\u308a\u3064\u3044\u305f\u3068\u3053\u308d\u3067\u3059\u3002\u300c\u5897\u3084\u305b\u3070\u5f37\u304f\u306a\u308b\u300d\u306f\u81ea\u660e\u306b\u3082\u601d\u3048\u307e\u3059\u304c\u3001\u305d\u3093\u306a\u5358\u7d14\u3067\u3082\u306a\u3044\u3068\u601d\u3063\u3066\u5b9f\u9a13\u3057\u306a\u304b\u3063\u305f\u3067\u3057\u3087\u3046\u3002\u5b9f\u969b\u3001\u7d50\u5408\u90e8\u4f4d\u309210\u5897\u3084\u3059\u3068\u9006\u306b\u6d3b\u6027\u304c\u4e0b\u304c\u3063\u305f\u3057\u3001<a href=\"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=4325\">\u4ee5\u524d\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u5f37\u5316\u3067\u3082\u5931\u6557\u3057\u305f\u3088\u3046\u306b<\/a>\u3001\u751f\u7269\u5b9f\u9a13\u306f\u3084\u3063\u3066\u307f\u306a\u3044\u3068\u5206\u304b\u3089\u306a\u3044\u3053\u3068\u304c\u3068\u3066\u3082\u591a\u3044\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u305d\u308c\u3067\u7d50\u5c40\u3001\u5f53\u521d\u306e\u76ee\u7684\u3092\u9054\u3057\u305f\u306e\u304b\u3068\u3044\u308f\u308c\u308b\u3068\u3001\u5b9f\u306f\u307e\u3060\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002P36<em>pro<\/em>\u3068\u591a\u30b3\u30d4\u30fc\u30d7\u30e9\u30b9\u30df\u30c9\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u300150\uff05\u307b\u3069\u7121\u5bb3\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3067\u304d\u305f\u306e\u3067\u3059\u304c\u3001\u9175\u6bcd\u306f\u307e\u3060\u5897\u6b96\u3057\u3066\u3044\u307e\u3059\uff08\uff4dRNA\u3082\u540c\u3058\u304f\u3089\u3044\u4f5c\u3063\u3066\u307e\u3059\uff09\u3002\u9175\u6bcd\u306b\u306f\u7533\u3057\u8a33\u306a\u3044\u3067\u3059\u304c\u3001\u3082\u3063\u3068\u5f37\u3044\u767a\u73fe\u7cfb\u304c\u5fc5\u8981\u306e\u3088\u3046\u3067\u3059\u3002\uff65\uff65\uff65\u305f\u3060\u3001\u305d\u308c\u306b\u95a2\u3057\u3066\u3046\u307e\u304f\u884c\u304d\u305d\u3046\u306a\u7d50\u679c\u304c\u51fa\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3082\u307e\u305f\u4e88\u60f3\u5916\u306e\u5b9f\u9a13\u7d50\u679c\u304b\u3089\u59cb\u307e\u3063\u3066\u3044\u3066\u3001\u305d\u308c\u3082\u3044\u3064\u304b\u307e\u305f\u89e3\u8aac\u3057\u305f\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Kotopka BJ, Smolke CD. Model-driven generation of artificial yeast promoters. Nat Commun. 2020 Apr 30;11(1):2113. doi: 10.1038\/s41467-020-15977-4. PMID: 32355169; PMCID: PMC7192914.<\/li>\n\n\n\n<li>McIsaac RS, Gibney PA, Chandran SS, Benjamin KR, Botstein D. Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae. Nucleic Acids Res. 2014 Apr;42(6):e48. doi: 10.1093\/nar\/gkt1402. Epub 2014 Jan 20. PMID: 24445804; PMCID: PMC3973312.<\/li>\n\n\n\n<li>McIsaac RS, Oakes BL, Wang X, Dummit KA, Botstein D, Noyes MB. Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast. Nucleic Acids Res. 2013 Feb 1;41(4):e57. doi: 10.1093\/nar\/gks1313. Epub 2012 Dec 28. PMID: 23275543; PMCID: PMC3575806.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Improving the Z&#8230;<\/p>\n","protected":false},"author":3,"featured_media":4488,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[25,133,1,8,137,9],"tags":[],"class_list":["post-4474","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-25","category-133","category-updates","category-8","category-137","category-9"],"_links":{"self":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4474","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4474"}],"version-history":[{"count":5,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4474\/revisions"}],"predecessor-version":[{"id":4491,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/4474\/revisions\/4491"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/media\/4488"}],"wp:attachment":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4474"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4474"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4474"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}