{"id":495,"date":"2012-03-22T19:21:28","date_gmt":"2012-03-22T10:21:28","guid":{"rendered":"http:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=495"},"modified":"2012-03-22T19:21:28","modified_gmt":"2012-03-22T10:21:28","slug":"hsp90%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e3%81%af%e7%95%b0%e6%95%b0%e6%80%a7%e3%82%92%e8%aa%98%e5%b0%8e%e3%81%97%e3%80%81%e7%b4%b0%e8%83%9e%e3%81%ae%e6%80%a5%e9%80%9f%e3%81%aa%e9%81%a9%e5%bf%9c","status":"publish","type":"post","link":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/?p=495","title":{"rendered":"Hsp90\u30b9\u30c8\u30ec\u30b9\u306f\u7570\u6570\u6027\u3092\u8a98\u5c0e\u3057\u3001\u7d30\u80de\u306e\u6025\u901f\u306a\u9069\u5fdc\u3092\u53ef\u80fd\u306b\u3059\u308b\u3002"},"content":{"rendered":"

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy.<\/a><\/p>\n

\n

Chen G, Bradford WD, Seidel CW, Li R.\u00a0Nature. 2012 Jan 29;482(7384):246-50. doi: 10.1038\/nature10795.\u00a0PMID:22286062<\/p>\n

Hsp90\u306f\u5206\u5b50\u30b7\u30e3\u30da\u30ed\u30f3\u306e\uff11\u3064\u3067\u3059\u304c\u3001\u9032\u5316\u5b66\u4e0a\u975e\u5e38\u306b\u8208\u5473\u6df1\u3044\u5206\u5b50\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u304c\u300c\u9032\u5316\u7684\u30ad\u30e3\u30d1\u30b7\u30bf\u30fc\u300d\u3068\u3044\u3046\u3082\u306e\u3067\u3001\u300c\u5b89\u5b9a\u306a\u74b0\u5883\u4e0b\u3067\u306f\u3001\u6f5c\u5728\u7684\u3067\u30de\u30a4\u30ca\u30fc\u306a\u5909\u7570\u306b\u3088\u308b\u86cb\u767d\u8cea\u306e\u6a5f\u80fd\u640d\u5931\u3092HSP90\u304c\u6700\u5c0f\u9650\u306b\u3068\u3069\u3081\u3001\u751f\u5b58\u306b\u4e0d\u5229\u76ca\u306a\u74b0\u5883\u306b\u306a\u3063\u305f\u6642\u306b\u3053\u308c\u3092\u4e00\u6c17\u306b\u89e3\u653e\u3057\u3066\u8868\u73fe\u578b\u306e\u591a\u69d8\u6027\u3092\u751f\u307f\u3060\u3059\u300d\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3059\u3002<\/p>\n

\u30ad\u30e3\u30d1\u30b7\u30bf\u30fc\u3068\u306f\u3001\u65e5\u672c\u8a9e\u3067\u306f\u30b3\u30f3\u30c7\u30f3\u30b5\u30fc\u3068\u3044\u308f\u308c\u3066\u3044\u308b\u96fb\u5b50\u90e8\u54c1\u3067\u3001\u96fb\u6c17\u3092\u6e9c\u3081\u8fbc\u3093\u3067\u653e\u51fa\u3059\u308b\u3068\u3044\u3046\u7279\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u50cd\u304d\u306b\u4f3c\u3066\u3044\u308b\u306e\u3067\u30ad\u30e3\u30d1\u30b7\u30bf\u30fc\u3068\u540d\u4ed8\u3051\u305f\u3068\u3044\u3046\u8a33\u3067\u3059\u3002<\/p>\n

\u3055\u3066\u3001\u3053\u306e\u8ad6\u6587\u3067\u306f\u9175\u6bcd\u306b\u304a\u3044\u3066\u3001\u305d\u306eHsp90\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\u3068\u67d3\u8272\u4f53\u5206\u96e2\u306e\u7570\u5e38\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u3066\u3001\u7570\u6570\u4f53\u304c\u9ad8\u983b\u5ea6\u3067\u751f\u3058\u3066\u3057\u307e\u3046\u3053\u3068\u3092\u307e\u305a\u898b\u3044\u3060\u3057\u3066\u3044\u307e\u3059\u3002Hsp90\u306f\u67d3\u8272\u4f53\u5206\u914d\u306b\u95a2\u308f\u308b\u30ad\u30cd\u30b3\u30a2\u86cb\u767d\u8cea\u306e\u30b7\u30e3\u30da\u30ed\u30f3\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u306e\u3067\u3001\u3053\u306e\u7570\u5e38\u304c\u7570\u6570\u6027\u3092\u751f\u3093\u3060\u3088\u3046\u3067\u3059\u3002<\/p>\n

\u305d\u3046\u3057\u3066\u3067\u304d\u305f\u7570\u6027\u4f53\u306e\u96c6\u56e3\u306f\u3044\u308d\u3044\u308d\u306a\u7d44\u307f\u5408\u308f\u305b\u306e\u67d3\u8272\u4f53\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u9175\u6bcd\u306e2\u500d\u4f53\u9175\u6bcd\u306e32\u672c\u306e\u67d3\u8272\u4f53\u306e\u3046\u30611\u672c\u304c\u5931\u308f\u308c\u3066\u3044\u305f\u308a\u30011\u672c\u304c\u5897\u3048\u3066\u3044\u305f\u308a\u30fb\u30fb\u30fb\u3002\u305d\u3057\u3066\u3001\u305d\u306e\u96c6\u56e3\u3092\u7279\u5b9a\u306e\u85ac\u306b\u6652\u3059\u3068\u3001\u305d\u306e\u85ac\u306e\u4f5c\u7528\u306b\u3088\u3063\u3066\u7279\u5b9a\u306e\u67d3\u8272\u4f53\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u3082\u3063\u305f\u7d30\u80de\u304c\u9078\u629e\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u7570\u6570\u6027\u306e\u304a\u304b\u3052\u3067\uff08\u85ac\u5264\u5b58\u5728\u4e0b\u3068\u3044\u3046\uff09\u74b0\u5883\u306b\u9069\u5fdc\u3067\u304d\u308b\u7d30\u80de\u304c\u751f\u307e\u308c\u3066\u304d\u305f\u306e\u3067\u3059\u3002<\/p>\n

\u7570\u6570\u4f53\u306f\u901a\u5e38\u306e\u6761\u4ef6\u3067\u306f\u5897\u6b96\u304c\u9045\u304f\u306a\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u85ac\u5264\u74b0\u5883\u306b\u9069\u5fdc\u3057\u305f\u7570\u6570\u4f53\u3092\u3082\u3068\u306e\u85ac\u306e\u306a\u3044\u74b0\u5883\u306b\u623b\u3057\u3066\u3084\u308b\u3068\u3001\u67d3\u8272\u4f53\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u3082\u3068\u306e\u91ce\u751f\u578b\u306b\u623b\u3063\u305f\u7d30\u80de\uff08\u6b63\u500d\u6570\u4f53\uff09\u304c\u73fe\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u3053\u306e\u3088\u3046\u306a\u3053\u3068\u304b\u3089\u7b46\u8005\u3089\u306f\u3001Hsp90\u304c\u74b0\u5883\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u50cd\u304d\u3001\u30b9\u30c8\u30ec\u30b9\u74b0\u5883\u3067Hsp90\u306e\u6a5f\u80fd\u304c\u4e0b\u304c\u308b\u3053\u3068\u3067\u7570\u6570\u4f53\u96c6\u56e3\u304c\u751f\u307e\u308c\u3001\u305d\u308c\u304c\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308a\u9078\u629e\u3092\u3046\u3051\u308b\u3053\u3068\u3067\u7a2e\u304c\u9069\u5fdc\u3057\u3001\u307e\u305f\u74b0\u5883\u304c\u623b\u308b\u3068\u6025\u901f\u306b\u3082\u3068\u306e\u6b63\u500d\u6570\u4f53\u306b\u623b\u308b\u3088\u3046\u306a\u30b7\u30b9\u30c6\u30e0\u304c\u3042\u308b\u306e\u3060\u308d\u3046\u3068\u7d50\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u67d3\u8272\u4f53\u306e\u6570\u3092\u5909\u3048\u3066\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u4ed5\u7d44\u307f\u304c\u3042\u308b\u3068\u3044\u3046\u306e\u306f\u5927\u5909\u9762\u767d\u3044\u8003\u3048\u3067\u3001\u305d\u308c\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304c\u30ad\u30e3\u30d1\u30b7\u30bf\u30fc\u3067\u3042\u308bHsp90\u3060\u3068\u3044\u3046\u306e\u3067\u3059\u3002Hsp90\u5929\u6674\u308c\uff01\uff1f<\/p>\n

 <\/p>\n<\/div>\n

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Hsp90 stress po…<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[8,9],"tags":[],"class_list":["post-495","post","type-post","status-publish","format-standard","hentry","category-8","category-9"],"_links":{"self":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=495"}],"version-history":[{"count":1,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/495\/revisions"}],"predecessor-version":[{"id":496,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=\/wp\/v2\/posts\/495\/revisions\/496"}],"wp:attachment":[{"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tenure5.vbl.okayama-u.ac.jp\/HM_blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}