原著論文 - HM's website

原著論文†

これらの論文の日本語での解説と、論文にまつわるエピソードは、成果発表/論文発表をご覧ください。

Kintaka R, Makanae K, Namba S, Kato H, Kito K, Ohnuki S, Ohya Y, Andrews BJ, Boone C, Moriya H., Genetic profiling of protein burden and nuclear export overload., Elife. 2020 Nov 04;9:.
Ishikawa K, Ishihara A, Moriya H., Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes., PLoS Genet. 2020 Oct;16(10):e1009091.
Saeki N, Eguchi Y, Kintaka R, Makanae K, Shichino Y, Iwasaki S, Kanno M, Kimura N, Moriya H., N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae., Sci Rep. 2020 Jun 11;10(1):9500.
Moriya H., The expression level and cytotoxicity of green fluorescent protein are modulated by an additional N-terminal sequence., AIMS Biophysics 2020, 7(2): 121-132 doi: 10.3934/biophy.2020010
Nemoto M, Iwaki S, Moriya H, Monden Y, Tamura T, Inagaki K, Mayama S, Obuse K., Comparative Gene Analysis Focused on Silica Cell Wall Formation: Identification of Diatom-Specific SET Domain Protein Methyltransferases., Mar Biotechnol (NY). 2020 Jun 03;:.
Mori Y, Yoshida Y, Satoh A, Moriya H., Development of an experimental method of systematically estimating protein expression limits in HEK293 cells., Sci Rep. 2020 Mar 16;10(1):4798.
Abe-Kanoh N, Kunisue N, Myojin T, Chino A, Munemasa S, Murata Y, Satoh A, Moriya H, Nakamura Y., Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12., Sci Rep. 2019 06 20;9(1):8866.
Eguchi Y, Makanae K, Hasunuma T, Ishibashi Y, Kito K, Moriya H., Estimating the protein burden limit of yeast cells by measuring the expression limits of glycolytic proteins., Elife. 2018 08 10;7:.
Scharff-Poulsen P, Moriya H, Johnston M., Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of ., G3 (Bethesda). 2018 Jun 28;:.
Miura T, Moriya H, Iwai S., Assessing phagotrophy in the mixotrophic ciliate Paramecium bursaria using GFP-expressing yeast cells., FEMS Microbiol Lett. 2017 Jul 03;364(12):.
Ishikawa K, Makanae K, Iwasaki S, Ingolia NT, Moriya H., Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes., PLoS Genet. 2017 Jan 25;13(1):e1006554.
Kintaka R, Makanae K, Moriya H., Cellular growth defects triggered by an overload of protein localization processes., Sci Rep. 2016;6:31774.
Moriya H., Quantitative nature of overexpression experiments., Mol Biol Cell. 2015 Nov 5;26(22):3932-9.
Bonney ME, Moriya H, Amon A., Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes., Genes Dev. 2015 May 1;29(9):898-903.
Makanae K, Kintaka R, Ishikawa K, Moriya H., Small Toxic Protein Encoded on Chromosome VII of Saccharomyces cerevisiae., PLoS One. 2015;10(3):e0120678.
Sasabe M, Shintani S, Kintaka R, Kaizu K, Makanae K, Moriya H., Evaluation of the lower protein limit in the budding yeast Saccharomyces cerevisiae using TIPI-gTOW., BMC Syst Biol. 2014 Jan 7;8(1):2.
Tsunematsu Y, Ishikawa N, Wakana D, Goda Y, Noguchi H, Moriya H, Hotta K, Watanabe K., Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk., Nat Chem Biol. 2013 Dec;9(12):818-25.
Chino A, Makanae K, Moriya H., Relationships between Cell Cycle Regulator Gene Copy Numbers and Protein Expression Levels in Schizosaccharomyces pombe., PLoS One. 2013;8(9):e73319.
Yamanishi M, Ito Y, Kintaka R, Imamura C, Katahira S, Ikeuchi A, Moriya H, Matsuyama T., A Genome-Wide Activity Assessment of Terminator Regions in Saccharomyces cerevisiae Provides a ″Terminatome″ Toolbox., ACS Synth Biol. 2013 Feb 20;:.
Naito T, Yatsuhashi A, Kaji N, Ando T, Sato K, Moriya H, Kitano H, Yasui T, Tokeshi M, Baba Y., Parallel Real-Time PCR on a Chip for Genetic Tug-of-War (gTOW) Method., Anal Sci. 2013;29(3):367-71.
Makanae K, Kintaka R, Makino T, Kitano H, Moriya H., Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method., Genome Res. 2013 Feb;23(2):300-11.
Moriya H, Makanae K, Watanabe K, Chino A, Shimizu-Yoshida Y., Robustness analysis of cellular systems using the genetic tug-of-war method., Mol Biosyst. 2012 Oct;8(10):2513-22.
Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto S, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H, Hotta K, Moriya H, Watanabe K., Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics., Chembiochem. 2012 Apr 16;13(6):846-54.
Moriya H, Chino A, Kapuy O, Csikász-Nagy A, Novák B., Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico., Mol Syst Biol. 2011;7:556.
Kaizu K, Ghosh S, Matsuoka Y, Moriya H, Shimizu-Yoshida Y, Kitano H., A comprehensive molecular interaction map of the budding yeast cell cycle., Mol Syst Biol. 2010 Sep 21;6:415.
Kaizu K, Moriya H, Kitano H., Fragilities caused by dosage imbalance in regulation of the budding yeast cell cycle., PLoS Genet. 2010;6(4):e1000919.
Chino A, Watanabe K, Moriya H., Plasmid Construction Using Recombination Activity in the Fission Yeast Schizosaccharomyces pombe., PLoS One. 2010;5(3):e9652.
Moriya H, Shimizu-Yoshida Y, Kitano H., In vivo robustness analysis of cell division cycle genes in Saccharomyces cerevisiae., PLoS Genet. 2006 Jul;2(7):e111.
Kim JH, Brachet V, Moriya H, Johnston M., Integration of transcriptional and posttranslational regulation in a glucose signal transduction pathway in Saccharomyces cerevisiae., Eukaryot Cell. 2006 Jan;5(1):167-73.
Ishiyama T, Dharmarajan S, Hayama M, Moriya H, Grapperhaus K, Patterson GA., Inhibition of nuclear factor kappaB by IkappaB superrepressor gene transfer ameliorates ischemia-reperfusion injury after experimental lung transplantation., J Thorac Cardiovasc Surg. 2005 Jul;130(1):194-201.
Moriya H, Johnston M., Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I., Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1572-7.
Moriya H, Shimizu-Yoshida Y, Omori A, Iwashita S, Katoh M, Sakai A., Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal., Genes Dev. 2001 May 15;15(10):1217-28.
Moriya H, Isono K., Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae., Yeast. 1999 Apr;15(6):481-96.
Moriya H, Kasai H, Isono K., Cloning and characterization of the hrpA gene in the terC region of Escherichia coli that is highly similar to the DEAH family RNA helicase genes of Saccharomyces cerevisiae., Nucleic Acids Res. 1995 Feb 25;23(4):595-8.