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The gTOW method used here is unusual and provides accurate and in many cases surprising results, such as the extreme copy numbers attainable for most cell cycle regulators described in the previous work. The integration with the modeling approach of Chen et al is also unusual and useful, since it provides a more broad-spectrum examination of the validity of this model, using data qualitatively different from those used in model generation. Finally, this method, with modifications, should be useful in many contexts